Page 807 - Veterinary Immunology, 10th Edition

Vaccine-Induced Osteodystrophy, 283
VetBooks.ir Injection Site–Associated Sarcomas, 283

Adverse Effect Principles, 283

Production, Presentation, and Control of Vaccines, 283

LEARNING OBJECTIVES

After reading this chapter, you should be able to:

• Explain how the use of any vaccine should be determined by a careful
assessment of the relative risks and benefits to an animal.

• Understand why vaccines differ in their importance and thus should be ranked
accordingly.
• Understand why unnecessary or over-frequent vaccination should be

discouraged.
• Understand the advantages and disadvantages of multiple antigen vaccines.
• Understand and explain the critical importance of the correct timing of

vaccination in young animals.
• Understand why vaccines should only be administered in the doses and by the
routes recommended by the manufacturer.

• Understand why, on occasion, vaccines may cause adverse effects in animals.
These are often mild but may be life threatening.

• Explain again why one cannot effectively vaccinate neonatal animals.
• Identify the major causes of vaccination failure.
• Understand the reasons why some animals will not respond to some vaccines.
• Identify the major adverse events that may be associated with vaccine use.

• Define vaccine failure, vaccine efficacy, and preventable fraction.

Although the principles of vaccination have been known for many
years, vaccines and vaccination procedures are continuing to
improve in efficacy and safety. The earliest veterinary vaccines

were often of limited efficacy and some had significant adverse
effects, although these were considered acceptable when measured

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