Page 873 - Veterinary Immunology, 10th Edition

Adverse Consequences of Immunity to Viruses, 305
VetBooks.ir Antibody-Dependent Enhancement, 305

Some Selected Virus Diseases, 306

Feline Infectious Peritonitis, 306

Aleutian Disease of Mink, 307

Equine Infectious Anemia, 308

Porcine Respiratory and Reproductive

Syndrome, 308

Some Antiviral Vaccines, 308
Serology of Viral Diseases, 309

Tests to Detect and Identify Viruses, 309

Tests to Detect and Identify Antiviral

Antibodies, 309

LEARNING OBJECTIVES

After reading this chapter, you should be able to:

• Describe how viral nucleic acids are detected by TLRs and other PRRs, and as a
result, are triggered to produce antiviral type I interferons.
• Summarize the antiviral mechanisms of interferons.

• List the different types of interferons and their biological significance.
• Explain why antibodies are effective against extracellular viruses.
• Describe why T cell–mediated responses are primarily responsible for antiviral

immunity.
• Explain how viruses employ a wide variety of methods to evade immune
destruction.

• Explain how some viruses employ sequential antigenic variation and describe its
consequences.
• Discuss how significant damage and disease may be caused by the immune

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