Page 885 - Veterinary Immunology, 10th Edition
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from viruses in the cytoplasm. They act on adenosine triphosphate
VetBooks.ir (ATP) to form 2′5′ adenylate oligomers. These oligomers bind and
activate a ribonuclease called RNAase L (Fig. 27.5). RNAase L
degrades viral RNA and so inhibits viral growth.
FIG. 27.5 Some of the mechanisms by which the interferons can
exert their antiviral activities. IFNAR: Interferon alpha/beta receptor.
OAS: Oligoadenylate synthetase. ISG: Interferon-stimulated genes.
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