Page 938 - Veterinary Immunology, 10th Edition

25 production. In the presence of parasitic helminths, the IL-25
VetBooks.ir promotes hyperplasia of tuft cells as well as mucus-producing

goblet cells. The IL-13 acts together with IL-4 to increase gut
motility and mucus production. The combination of increased

motility with increased mucus production can expel many
helminth parasites.

FIG. 28.10 The mechanisms by which tuft cells participate in
parasite expulsion.

In response to these stimuli, T cells release their own effector
cytokines. For example, γ/δ T cells in the intestinal epithelium
produce IL-4 and IL-25. Likewise, Th2 cells produce more IL-4 in a

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