Page 962 - Veterinary Immunology, 10th Edition

enhance IgE production.
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FIG. 29.4 The allergy loop. Dendritic cells express FcεRI and as a
result can bind antigen-IgE complexes. This antigen, once
processed, stimulates Th2 responses. These Th2 cells in turn
secrete cytokines, which further promote the IgE response.

FcεRII (CD23), in contrast, is a selectin found on B cells, NK cells,
macrophages, dendritic cells, eosinophils, and platelets. In addition

to binding IgE, FcεRII also binds to the complement receptor CR2
(CD21) (Fig. 29.5). Thus B cells expressing FcεRII link to CR2 on
other B cells, T cells, and dendritic cells. By linking B cells to
dendritic cells in this way, FcεRII enhances B cell survival and

regulates IgE production.

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