Page 196 - Rule Outs in Small Animal Medicine, Problem-oriented Assessment of Problems in Physical Examination and Clinical Pathology, 2nd Edition

Basic laboratory diagnostics Basic laboratory diagnostics
Haemostaseology Haemostaseology

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Prolonged
prothrombin time
(prolonged optimised
quick test*)
Prolonged thrombin
time*

Disorder of the
coagulation
extrinsic pathway

Increased thrombin Increased thrombin
Reduced Vitamin K consumption degradation
activity

Competitive inhibition – DIC – Iatrogenic
Vitamin K deficiency
of vitamin K (therapy with heparin)

– Iatrogenic (therapy
Decreased Decreased with coumarine
production resorption derivatives)
– Rodenticide 1
intoxication

Reduced synthesis
Reduced fat
Hepatic dysfunction by intestinal
digestion
bacteria

– Liver fibrosis – Cholestasis – Dysbacteriosis
– Liver cirrhosis (e.g. therapy with
– Liver neoplasia antibiotics)
– Hepatic lipidosis

*

* Shortened prothrombin time is not clinically relevant * Shortened thrombin time nicht is not clinically relevant

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