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Natural Antioxidants: Occurrence and Their Role in Food Preservation  77
  VetBooks.ir  bran and rice germ which consists of a mixture of ferulic acid esters of PS


            and triterpene alcohols (Fig. 2.11). There are numerous reports indicating
            the benefits, efficacy, and safety of γ-OZ (Rukumini & Raghuram, 1991).




                                              26


                         0                              0
                                                      ""'
                      ""'
             H,co~         o                 H,CO~        o
                                                 I
                  I
              HO   .&-       28   29          HO   .&-
                   cycloartenol ferulate        24-methylenecycloartenol ferulate




                         0                              0
              3
             H CO~""'                        H3C0~        0
                 I
                          o
              HO   .&                         HO,Jl--J
                    campesferol ferulate            ~-sitosterol ferulate

                                        0
                             H3CO~O
                              HO~
                                    cyclobranol ferulate
            FIGURE 2.11  Different components of γ-oryzanol.




            2.15.1  HEALTH BENEFITS OF ORYZANOL

            Wilson et al. (2007) reported that γ-OZ reduced plasma cholesterol in hyper-
            cholesterolemic hamsters. Clinically, oral intake of rice bran oil (containing
            naturally occurring γ-OZ) has been shown to alleviate hypercholesterolemia
            and  hyperlipidemia.  γ-OZ  has  been  advocated  as  treatment  for  relieving
            menopausal symptoms. Besides, Oka et al. (2010) reported that cycloartenyl
            ferulate,  a  component  of  rice  bran  oil-derived  γ-OZ,  inhibits  mass  cells
            degranulation. The anti-inflammatory effects of γ-OZ in ulcerative colitis
            induced in mice have also been reported (Rukumini & Raghuram, 1991).
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