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105 Brucellosis 965

(5 mg/kg q12h for 30 days) has been described as success- Public Health Implications
VetBooks.ir ful in preserving fertility in a kennel outbreak situation, Due to zoonotic concern, B. canis is a reportable disease
although some dogs had persistently elevated antibodies
and subsequent treatments were required.
in most states. Human case reports are often limited to
laboratory workers and immunocompromised individu-
als. Most infections in people are mild although serious
Prognosis illness can occur. The disease may be underreported in
humans due to varying clinical symptoms, which may
As infected dogs rarely show clinical signs, prognosis for mimic other diseases. Krueger and workers showed in a
survival is excellent. However, since infected dogs remain 2014 study that based on serologic testing, kennel
a potential source for infection for other dogs and immu- employees and dog breeders are most likely to be exposed
nocompromised humans, they should be kept in isola- and many may have experienced Brucella‐associated ill-
tion from these individuals. Infected dogs should not be ness without diagnosis. Fortunately, humans respond
used for breeding and infection may be devastating to a well to antibiotic therapy and the disease is cleared when
breeding kennel due to its rapid spread. treated appropriately long term.

Further Reading

Boeri EJ, Wanke MM, Madariaga MJ, et al. Comparison of Hensel ME, Negron M, Arenas‐Gamboa AM. Brucellosis
four polymerase chain reaction assays for the detection in dogs and public health risk. Emerg Infect Dis 2018;
of Brucella spp. in clinical samples from dogs. Vet World 24(8): 1401–6.
2018; 11(2): 201–8. Krueger WS, Lucero NE, Brower A, et al. Evidence for
Dentinger CM, Jacob K, Lee LV, et al. Human unapparent Brucella canis infections among adults with
Brucella canis infection and subsequent occupational exposure to dogs. Zoonoses Public Health
laboratory exposures associated with a puppy, 2014; 61(7): 509–18.
New York City, 2012. Zoonoses Public Health Makloski CL. Canine brucellosis management. Vet Clin
2014; 62(5): 407–14. North Am Small Anim Pract 2011; 41: 1209–19.
Graham EM, Taylor DJ. Bacterial reproductive pathogens Wanke MM, Delpino MV, Baldi PC. Use of enrofloxacin in
of dogs and cats. Vet Clin North Am Small Anim Pract the treatment of canine brucellosis in a dog kennel
2012; 42: 561–82. (clinical trial). Theriogenology 2006; 66(6‐7): 1573–8.