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130 Biology of Cancer and Cancer Genetics 1211

Conclusion appreciation that each hallmark operates as part of a
VetBooks.ir Hanahan and Weinberg’s hallmarks of cancer provides greater circuit will promote discoveries that further
advance the study of veterinary cancer and clinical oncol-
ogy. The advancements made by veterinary researchers
an incredibly useful conceptual framework for under-
standing the complex biology of cancer, and it is evident and clinician scientists featured in this chapter have con-
that intimate associations link each. The categorical tributed to a greater understanding of translational
focus of these cancer principles allows the specialized oncologic concepts between human and companion ani-
refinement of molecular mechanisms; however, the mal cancer patients.

Further Reading

Boss M‐K, Bristow R, Dewhirst MW. Linking the history of Ruetgen BC, Willenbrock S, Reimann‐Berg N, et al.
radiation biology to the hallmarks of cancer. Radiat Res Authentication of primordial characteristics of the
2014; 181(6): 561–77. CLBL‐1 cell line prove the integrity of a canine B‐cell
Grassi Rici RE, Alcantara D, Fratini P, et al. Mesenchymal lymphoma in a murine in vivo model. PLoS One 2012;
stem cells with rhBMP‐2 inhibits the growth of canine 7(6): e40078.
osteosarcoma cells. BMC Vet Res 2012; 8: 17. Seguin B, Zwerdling T, McCallan JL, et al. Development of
Hanahan D, Weinberg RA. Hallmarks of cancer: the next a new canine osteosarcoma cell line. Vet Compar Oncol
generation. Cell 2011; 144(5): 646–74. 2006; 4(4): 232–40.