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134 Lymphomas 1239

Nasal Lymphoma Cats with high‐grade alimentary lymphoma treated
VetBooks.ir radiation therapy may be indicated as a sole treatment. with a multiagent chemotherapy protocol can respond
If nasal lymphoma is confirmed to be nonsystemic, local
with median survival times of 210 days. A positive

Cats achieving a complete or partial remission have a
Other Anatomic Locations response to treatment is the best prognostic indicator.
Other infrequently encountered forms of lymphoma in significantly longer survival time of >2 years.
the cat include laryngeal or tracheal. Cats presenting Cats with nasal lymphoma can enjoy lengthy survival
with disease isolated to these locations can respond times of 1–3 years or more with radiation therapy
positively to local radiation therapy +/‐ chemotherapy +/‐ chemotherapy.
for periods of 6–12 months. Central nervous system and renal lymphoma are
uncommon but when encountered, cats can experience a
short period of clinical benefit from chemotherapy and/
Prognosis
or radiation therapy for a median of 2–6 months.
Generally, the overall response rate and survival time in
cats are much lower than those achieved in dogs.
However, this varies and is determined by the anatomic Conclusion
location at presentation, grade of tumor, and viral status
of the cat. Cats and dogs with lymphoma can respond favorably to
High‐grade tumors progress rapidly but are more chemotherapy +/‐ radiation therapy. The treatments are
likely to respond to multiagent chemotherapy for a generally well tolerated with most animals achieving a
finite period of time, whereas low‐grade tumors pro­ clinical benefit for variable periods of time. Prognosis is
gress slowly and can be easily managed as chronic dependent on location, extent of disease, histologic
diseases. grade, and phenotype. Cancer treatment in pets can be a
Cats with mediastinal lymphoma respond well to rewarding experience. Most pet owners appreciate the
chemotherapy initially, but the duration of response is dedication of the veterinarian and the additional quality
usually short‐lived (2–3 months). time they gain with their pets.

Further Reading

Simon D, Eberle N, Laacke‐Singer L, Nolte I. Combination immunoreactivity and their association with prognosis
chemotherapy in feline lymphoma: treatment, outcome, in 90 cats. J Vet Intern Med 1998; 12: 349–54.
tolerability and duration in 23 cats. J Vet Intern Med Vail DM, Pinkerton ME, Young KM. Hematopoietic
2008; 22: 394–400. tumors. In: Withrow S, Vail DM, Page RL, eds. Small
Thamm DH, Vail DM, Post GS, et al. Alternating Animal Clinical Oncology, 5th edn. St Louis, MO:
rabacfosadine/doxorubicin: efficacy and tolerability in Elsevier Saunders, 2013, pp.608–50.
naïve canine multicentric lymphoma. J Vet Intern Med Vezzali E, Parodi AL, Marcato PS, Bettini G.
2017; 231(3): 872–8. Histopathological classification of 171 cases of canine
Vail DM, Moore AS, Ogilvie GK, Volk LM. Feline and feline non‐Hodgkin lymphoma according to the
lymphoma (145 cases): proliferation indices, CD3 WHO. Vet Comp Oncol 2010; 8: 38–49.