Page 1357 - Clinical Small Animal Internal Medicine

143 Exocrine Pancreatic Cancer 1295

In a retrospective study evaluating 34 cats with EPC, Comparatively, about 45 220 people develop cancer of
VetBooks.ir metastatic disease was confirmed in 11 cats and overall the exocrine pancreas each year in the US, and almost all
are expected to die from the disease. The median sur-
median survival was 97 days. The median survival times
for patients who received chemotherapy or had their
disease and less for those with metastatic disease at pres-
masses surgically removed was 165 days. Patients with vival is 8–12 months for patients with locally advanced
abdominal effusion present at diagnosis had a median entation. Five‐year survival rates are consistently <18%.
survival of 30 days. Interestingly, however, three patients The majority of these tumors (85%) are adenocarcino-
survived over one year. mas arising from the ductal epithelium. Surgical resec-
A cat with metastatic EPC to the spleen treated with tion offers the only chance of cure. However, only
partial pancreatectomy and splenectomy was reported 15–20% of patients have resectable disease at diagnosis,
to be alive and disease free >2 years later. Therefore, the approximately 40% have metastatic disease, and another
prognosis for EPC in select dogs and cats may not be as 30–40% have locally advanced unresectable tumors.
dismal as previously reported.

Further Reading

Bennett PF, Hahn KA, Toal RL, Legendre AM. Miller WH, Griffin CE, Campbell KL. Paraneoplastic
Ultrasonographic and cytopathological diagnosis of alopecia. Muller and Kirk’s Small Animal Dermatology,
exocrine pancreatic carcinoma in the dog and cat. J Am 7th edn. Philadelphia, PA: Saunders 2013, pp. 558–9.
Anim Hosp Assoc 2001; 37(5): 466–73. Rosatelli P, Menicagli F, Citro G, Baldi A, Spugnini EP.
Dennis MM, O’Brien TD, Wayne T, Kuipel M, Williams M, Long‐term survival in a cat with pancreatic carcinoma
Powers BE. Hyalinizing pancreatic adenocarcinoma in and splenic involvement after surgical excision. Case Rep
six dogs. Vet Pathol 2008; 45: 475–83. Vet Med 2011; 2011: article ID 653859.
Hecht S, Penninick DG, Keating JH. Imaging findings in Seaman RL. Exocrine pancreatic neoplasia in the cat: a
pancreatic neoplasia and nodular hyperplasia in 19 cats. case series. J Am Anim Hosp Assoc 2004; 40(3): 238–45.
Vet Radiol Ultrasound 2007; 48(1): 45–50. Shearin AL, Ostrander EA. Leading the way: canine
Linderman MJ, Brodsky EM., Lorimier LP, Clifford CA, models of genomics and disease. Dis Models
Post GA. Feline exocrine pancreatic carcinoma: a Mechanisms 2010; 3(1‐2): 27–3.
retrospective study of 34 cases. Vet Compar Oncol 2013;
11(3): 208–18