Page 1382 - Clinical Small Animal Internal Medicine

1320 Section 11 Oncologic Disease

Many dogs with metastatic ovarian carcinoma can study, cyclooxygenase 2 (COX‐2) was found to play a
VetBooks.ir present with secondary ascites. One study found that potential role in carcinogenesis and was expressed in
81% of canine ovarian carcinomas. Therefore, the use
the overall accuracy of using cytology to differentiate
ovarian carcinoma effusions from other types is approxi-
other urogenital tumors, should be considered for
mately 95%. of NSAID therapy, similar to what has been found in
ovarian carcinomas.
Therapy
Prognosis
A complete ovariohysterectomy is the treatment of
choice for dogs with ovarian tumors that have no The prognosis is excellent for solitary ovarian tumors that
evidence of metastasis and typically results in a cure. are completely excised with no evidence of metastasis. If
There are limited reports of dogs with metastatic metastatic disease is present, the prognosis is guarded
tumors. In one report, a dog was treated with cisplatin to poor, depending on the response to chemotherapy.
2
50 mg/m intraperitoneally for ovarian carcinomatosis, The use of platinum drugs and COX‐2 inhibitors is
resulting in long‐term control. In humans, platinum recommended.
drugs, taxanes, and monoclonal antibodies are consid- Treatment and prognosis are similar in cats. Surgery is
ered first‐line therapies. Based on human research and the treatment of choice, and if metastatic disease is
success with chemotherapy, platinum agents should be present, carboplatin (intravenous or intraperitoneal)
considered for metastatic ovarian tumors. In a recent and/or COX‐2 inhibitors are recommended.

Further Reading

Bertazzolo W, Bonfanti U, Mazzotti S, Gelain ME. Riccardi E, Grieco V, Verganti S, Finazzi M.
Cytologic features and diagnostic accuracy of analysis of Immunohistochemical diagnosis of canine ovarian
effusions for detection of ovarian carcinoma in dogs. epithelial and granulosa cell tumors. J Vet Diagn Invest
Vet Clin Pathol 2012; 41(1): 127–32. 2007; 19(4): 431–5.
Borzacchiello G, Russo V, Russo M. Immunohistochemical
expression of cyclooxygenase‐2 in canine ovarian
carcinomas. J Vet Med A 2007; 54(5): 247–9.