Page 1510 - Clinical Small Animal Internal Medicine

1448 Section 12 Skin and Ear Diseases

Furunculosis and suppurative inflammation have also infections are present. Oral cephalexin can be given at
VetBooks.ir been reported in advanced cases. 25–30 mg/kg q12h for the duration of the corticoster-
oid treatment. Ciclosporin has also been effective in
cases refractory to glucocorticoids. Griseofulvin was
Therapy
used with good results in six puppies at the dose range
Treatment consists of immunosuppressive doses of of 14.2–34 mg/kg q12h. All cases were completely
glucocorticoids. Initial treatment should be aggres- recovered within three weeks. The authors postulated
sive, as scarring can be severe if the disease is not con- that griseofulvin could induce downregulatory signals
trolled quickly. Oral prednisone or prednisolone can within the lesions.
be given at 2 mg/kg/day until lesions resolve, usually
2–4 weeks, and then slowly tapered off completely Prognosis
over the next few weeks. Some dogs may respond
better to oral dexamethasone at 0.2 mg/kg/day (initial The prognosis is good. Most cases respond well to treat-
dose). Antibiotics should be given if secondary bacterial ment and relapses are uncommon.

Further Reading

Affolter VK, Moore PF. Canine cutaneous and systemic Moore PF. A review of histiocytic diseases of dogs and
histiocytosis: reactive histiocytosis of dermal dendritic cats. Vet Pathol 2014; 51(1):167–84.
cells. Am J Dermatopathol 2000; 22(1): 40–8. Mullin C, Clifford CA. Histiocytic sarcoma and
Contreary CL, Outerbridge CA, Affolter VK, et al. Canine hemangiosarcoma update. Vet Clin North Am Small Anim
sterile nodular panniculitis: a retrospective study of 39 Pract 2019; 49(5): 855–879.
dogs. Vet Dermatol 2015; 26(6): 451–8. Paździor‐Czapula K, Rotkiewicz T, Otrocka‐Domagała I, et al.
Miller WH, Griffin CE, Campbell KL, eds. Muller and Morphology and immunophenotype of canine cutaneous
Kirk’s Small Animal Dermatology, 7th edn. St Louis, histiocytic tumours with particular emphasis on diagnostic
MO: Elsevier, 2013. application. Vet Res Commun 2015; 39(1): 7–17.