Page 899 - Veterinary Immunology, 10th Edition

hepatitis), an immune-complex–mediated uveitis and a focal
VetBooks.ir glomerulonephritis both develop. The uveitis, commonly called

“blue-eye,” is seen both in dogs with natural infections and in those
vaccinated with live attenuated adenovirus vaccine (Fig. 27.8). The

uveitis results from the formation of virus-antibody complexes in
the anterior chamber of the eye and in the cornea with complement
activation and consequent neutrophil accumulation. The
neutrophils release enzymes and oxidants that damage corneal

epithelial cells, leading to edema and opacity. The condition
resolves spontaneously in about 90% of affected dogs.

FIG. 27.8 A case of blue-eye in a coyote puppy. This is a type III
hypersensitivity reaction to canine adenovirus 1 (ICH) occurring in
the cornea. (Courtesy Dr. G.J. Costanzo.)

In Borna disease, a lethal viral encephalitis, the noncytopathic
virus does not kill neurons. Infected animals do, however, mount a
strong Th1 response that results in neuronal destruction by T cells.
The development of bornaviral disease in both birds and mammals

can be prevented therefore by treatment with immunosuppressive
drugs such as cyclosporine.

Antibody-Dependent Enhancement

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