Page 177 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

Kstrophanthin B (a bioside) and

cymarin (a monoside).

Strophanthus gratus

The seeds of Strophathus gratus contains another glycoside named ouabain (G-
strophanthoside), which yields on hydrolysis rhamnose and the aglycone ouabagenin
(G-strophanthidin

Ouabain has a low bioavailability and after intravenous administration, the onset of
action occurs within 3-10 minutes in humans with the maximum effect enduring for 1.5
hours

Medical Uses (I.V): Small doses of ouabain can be used to treat hypotension and
cardiac arrhythmias.

Keller-Killiani’s test: is negative.. Why?

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