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Virus-mediated modulation of RAS in COVID-19 patients and influence of sex hormones
However, existing evidence, for other respiratory viral infections, viz. SARS, MERS and influenza, provides important clues in this regard. In an attempt to consolidate the available knowledge on this issue, a group of researchers from Etiologically Elusive Disorders Research Network (EEDRN), AIIMS Patna, and IIT Gandhinagar conducted a systematic review of the existing empirical knowledge and recent experimental studies following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The qualitative analysis of the collected data unravelled multiple molecular mechanisms, such as evolutionary and genetic/ epigenetic factors, sex-linkage of viral host cell entry receptor and immune response genes, sex hormone and gut microbiome-mediated immune-modulation, as the possible key reasons for the sex-based differences in patient outcomes in COVID-19.
Contact info:
drashutoshkumar@aiimspatna.org
Website link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353216/pdf/ S1462399421000090a.pdf
IIT Palakkad made a roadmap for investigation on the long-term
effects of COVID-19 in the context of airways diseases
As we all know the long-term effects of COVID-19 in the recovered patients are not yet elaborated. Prof. Jagadeesh Bayry is a part of the international consortium to identify research priorities to understand the long-term sequelae of COVID-19 in the population with pre- existing and new on-set airways diseases including chronic obstructive pulmonary disease and asthma. The consortium has identified the prognosis scores as the main area of future investigation. Emphasis was also laid on the prevalence and severity of post-COVID-19 fatigue, anxiety, depression, and risk of cardiovascular complications in such patients.
Website link:
https://iitpkd.ac.in/news/roadmap-investigation-long-term-effects-covid-19- context-airways-diseases
VOL. IV ISSUE 10
VIGYAN PRASAR 25
COVID-19 SCIENCE & TECHNOLOGY EFFORTS IN INDIA