Page 80 - Simplicity is Key in CRT

Figure 3. Kaplan-Meier estimates of the time to primary endpoint (combination of LVAD implantation, cardiac
transplantation or all-cause mortality) for A) ESC, B) AHA/ACC/HRS, C) MADIT, and D) Strauss LBBB definitions.
In each panel the black line represents patients classified as non-LBBB QRS morphology and the red line LBBB QRS morphology according to the respective definition.
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Diagnostic properties of the LBBB definitions are presented in table 4. LBBB according to the AHA/ACC/HRS definition had the highest specificity for predicting survival free from the primary endpoint (0.87) with a corresponding positive predictive value (PPV) of 0.77. The ESC LBBB definition had the highest sensitivity (0.82) with a corresponding negative predictive values (NPV) of 0.44. (Table 4) The AUC of the various LBBB definitions was similar for all LBBB definitions (0.53, [0.50, 0.56]), except for the ESC definition, which showed a significantly higher AUC (0.57, [0.54, 0.59], P=0.004).