Page 104 - Practical Technology 2025
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Clinical Pharmacy-Pharm D Level Three 2 Semester 2024/2025 Pharmaceutical Technology (PT 607)
%Deviation of quality control tests:
• Thickness: ± 5% or less of standard value.
• Diameter: not exceed ± 5% for tablets with diameter less than 12.5 and ± 3% for diameter
of 12.5 mm or more.
• Hardness (crushing strength):
➢ Chewable tablets are softer which have a hardness of 3 kg.
➢ Oral tablets normally have a hardness of 4 to 10 kg.
➢ Some sustained release tablets are much harder which have a hardness of 11 -20 kg.
• Uniformity of weight for tablets (USP):
➢ If the tab. Wt. 130 mg or less ------ +/- 10%
➢ If the tab. Wt. 131- 324 mg ------ +/- 7.5 %
➢ If the tab. Wt. more than 324 ------ +/- 5 %
No more than two tablets are outside the percentage limit and no tablet differs by more than
twice the percentage limit.
According to BP:
• Friability: Up to 1%.
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