Page 18 - Labatt Brain Tumour Research Centre Annual Report 2023 to 2024

YEAR IN REVIEWYear in Review – Currently Held Grants
Dr. Sunit Das
Next generation precision oncology for pediatric-type
AYA gliomas. Canadian Institutes of Health Research
Redefining the paradigm for surveillance in patients
with low-grade glioma using saturation transfer
magnetic resonance imaging. Canadian Institutes
of Health Research
Metabolic indicators of treatment response and
survivorship in glioblastoma. Meagan’s HUG
(Meagan Bebenek Foundation)
Integrated nanotechnology and biomedical sciences
library. Canadian Institutes of Health Research
Terry Fox New Frontiers Program project grant in
determinants of stemness that underlie high risk or
relapse disease. Terry Fox Research Institute (TFRI)
Reimagining glioblastoma as a consequence of
aberrant neural tissue repair. Canadian Cancer
Society
The new roads team – Innovative approaches to
curing brain tumours. Cancer Research UK
Targeting biological vulnerabilities of glioblastoma.
Cancer Research UK
Optimizing brain tumour surveillance in Canada.
Canadian Cancer Society
Assessing molecular, clinical and imaging
predictors of response, quality of life measures and
neurocognitive outcomes in young adult patients
with low grade glioma undergoing multimodality
therapy. Brain Tumour Foundation of Canada
Improving outcomes across the cancer journey for
adolescents and young adults with central nervous
systems tumours: The IMPACT-CNS Cohort.
Canadian Institutes of Health Research
Identifying the molecular signature of infiltrating
cells in glioblastoma as drivers of tumour invasion
and recurrence. b.r.a.i.n.child
Dr. Peter Dirks
Tracing the origins of DIPG. ChadTough Defeat
DIPG Foundation, Game Changer Grant
Uncovering the chromatin landscape that confers
the spatial-temporal cell context dependent
vulnerability to histone H3k27M. Meagan’s HUG
(Meagan Bebenek Foundation)
Brain Tumour Biobank at the Arthur and Sonia
Labatt Brain Tumour Research Centre (BTRC
Biobank). SickKids Garron Family Cancer Centre
Injury reprogramming at the root of glioblastoma
initiation and progression. Canadian Institutes of
Health Research
Drug discovery in glioblastoma invasion: Target
discovery and validation. Toronto Innovation
Acceleration Partners
Determining the cellular mechanisms of initiation
and evolution of hypermutant glioma. Canadian
Institutes of Health Research
Tracing the cellular and molecular origins of mouse
and human medulloblastoma. Canadian Institutes
of Health Research
Modeling brain cancer in regionally defined human
neural stem cell system. Canadian Institutes of
Health Research
Dr. Sean Egan
Apobec3, a hit-and-run driver responsible for
breast cancer initiation and/or progression?
United States Department of Defense, Breast
Cancer Research Program
16q hemizygous loss in breast cancer: The central
driver for tumor initiation, invasion and progression.
Canadian Institutes of Health Research
Apobec3A, is it a terrible addiction for breast
cancer, or a hit-and-run driver? Canadian Cancer
Society Research Institute
Does a K-Ras switch drive c-Met-induced EMT?
SickKids Garron Family Cancer Centre
Targeting the immune landscape at presentation
and relapse of immune-related lobular breast
cancer. Canadian Institutes of Health Research
APOBEC3, an endogenous mutagen driving breast
cancer progression. Canadian Research Society
Developing and credentialing murine models of
ILC. (Co-I) National Institutes of Health (US)
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IMAGINE 2023-24