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Table 6. Current Clinical trials of HIPEC in Ovarian Cancer

Type/Phase of Study/ Expected
HIPEC Regimen and Technique Completion Outcome Measures
Setting Cytoreduction Name Location NCTRN

Recurrence Randomised Rome Italy NCT01539785 Cisplatin (CDDP) 75 mg/m2 2018 PFI
HORSE Closed OS/ morbidity & mortality
Recurrence Technique of Intraperitoneal Chemotherapy: Normothermic and Hyperthermic 1301
Secondary

Recurrence Phase 2 Linz Austria NCT02487849 Carboplatin 800 mg/m2 2020 Side-effects and postoperative
Secondary Closed complications QOL, PFS 2 years

Recurrence Phase 3 France NCT01376752 Cisplatin 75 mg/m2 2018 OS 4 years
Secondary Randomised CHIPOR MSKCC USA 2018 PFS 4 years
NCT01767675 Carboplatin 800mg/m2
Recurrence Phase 2 Closed Progression free status,
Secondary Randomised Toxicity, complications,

pharmacokinetics

Frontline Phase 3 Italy NCT01628380 Cisplatin (CDDP) (100 mg/m2) 2018 DFS 2 years
Frontline IDS only + Paclitaxel (175 mg/m2) Mortality/morbidity
OS, Time to chemo
Randomised CHORINE Closed/open

Frontline Phase 3 Netherlands NCT00426257 Platinum 100 mg/m2 2016 PFS, Toxicity/ morbidity
Secondary/interval debulking Randomised QOL/ OS/ Tumour response

Frontline Phase 3 Murcia, Spain NCT02328716 Cisplatin 75 mg/m2 2015 DFS 30 months
Randomised OS, morbidity, QOL, ex-vivo studies
CARCINOHIPEC

Frontline Primary only Phase 2 Randomised Baltimore USA NCT02124421 Carboplatin AUC=6 2020 30 day post op complication rates
QOL, PFS/OS
CRS/HIPEC +IV C 6 vs CRS+IV-IP C6

Any

Frontline/ recurrence Phase 2/3 Korea NCT01091636 Cisplatin (75 mg/m2) 2017 PFS 2 years OS, QOL
Randomised 2018
Frontline/ Recurrence Ghent, Belgium NCT0256725 Cisplatin (75 mg/m2 and Translational
CRS+IPEC ( 2 doses) Phase 2 Randomised 120 mg/m2) Mortality, morbidity, QOL, survival
vs CRS + HIPEC (2 doses) OvIP1

PFI = progression free interval, PFS= progression free survival, OS = overall survival, QOL= quality of life, CRS = cytoreductive surgery, IPEC = intra peritoneal chemotherapy , IDS= interval
debulking surgery