Page 39 - Anemia Hemolitica No autoinmune

Hiperesplenismo
e., reticuloendo- d are generally ass through the
usoidal wall has one side and has al human adult a sphere of that ws an RBC with and deform suf- he excess surface area to volume . Any condition verse these sinu-
ficiently. cytosol and the
eform. Oxidant adjacent to the ent of the mem- g. Such cells are nd entering the
Cause
Neoplasia Infection
Portal bed obstruction Collagen vascular disease
Chronic inflammatory disease
Chronic hereditary or acquired hemolytic anemia
Lipoidosis
Amyloidosis
Tropical splenomegaly syndrome
Example
Lymphoma, hairy cell leukemia
Bacterial endocarditis, malaria, schistosomiasis, tuberculosis
Alcoholic cirrhosis, splenic vein thrombosis
Systemic lupus erythematosus, malignant phase of rheumatoid arthritis
Rheumatoid arthritis
Severe β-thalassemia, autoimmune hemolytic anemia
Gaucher disease
AL and AA types
Hyperreactive malarial splenomegaly syndrome
Table 45-1 Causes of Splenomegaly
. e
p n
m n
o ,
T e
4 a
f
d e
n
a
ability of splenic