Page 101 - phytochemistry I - PharmD Clinical

Safrole

Source: Sassafras oil.

Uses:

Flavoring for beverages and pharmaceutical preparations.
It was banned by FDA after its carcinogenicity in rats was discovered.
Today, safrole is also banned for use in soap and perfumes by the
International Fragrance Association.

Anisole
(Phenyl methyl ether)
Source: Oil of wintergreen.
Apiole

Source: Parsley seed oil.

Zeisels method for quantitative methoxyl determination:
This method depends on the splitting off the methyl group by constant
boiling with hydroiodic acid resulting in the formation of methyl iodide The
volatile methyl iodide is transferred quantitatively (by means of stream of
a carrier gas as CO2) into receiver containing alcoholic solution of AgNO3.
The methyl iodide reacts with AgNO3, forming the double salt AgI. AgNO3

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