Page 29 - phytochemistry I - PharmD Clinical

their systemic use.

Streptomycin

 Streptomycin is produced by Streptomyces griseus. It was introduced in
1943 primarily for the treatment of tuberculosis.

 The α-hydroxy aldehyde function is a center of instability such that
streptomycin cannot be sterilized by autoclaving, but instead sterilized by
ultrafiltration.

 It is rarely used today as a single agent, but with other primary drugs for
tuberculosis such as isonicotinic acid hydrazide, rifampin and p-
aminosalicylic acid.

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