Page 94 - phytochemistry I - PharmD Clinical

Camphorated Opium tincture (Paregoric has just 0.4 mg/mL of morphine);
This medication known for its antidiarrheal and analgesic properties.

Determination of aldehydes and ketones
1. The bisulphite method:

A measured quantity of the oil is shaken with hot aq. solution of sodium
bisulphite, a water soluble additive compounds is formed. the non-
aldehyde portion of the oil separates as an oily layer, which can be
measured using cassia flask.

2. The neutral sulphite method:

In this method neutral sulphite solution is used and sodium hydroxide is
liberated as the reaction proceeds and this must be periodically
neutralized with acid to permit the reaction to go to completion. This
method is specifically of importance for the determinant of carvone in
spearmint, dill and caraway oils.

 Those volatile oils which contain aldehydes in very small amounts, or
which contain other constituents that from water-soluble addition
products with sodium sulfite and bisulfite cannot be assayed
accurately by these methods.

 In those cases, aldehydes and ketones are generally determined by
the hydroxylamine method.

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