Page 102 - Aloe Vera Information - Scientific Papers about Aloe Vera

Percent inhibition d
Left -30.6 -25.4 -20.9 42.4
Right 67.3 17.6 32.0 79.7

a Initial body weight, 170-185 g.
b Symbols: +/-, standard error; and the negative value (-, minus) means swelling.
c Adjuvant arthritis with 0.1 mg/kg H O x 13, day 0-12.
2
d Percent difference from aqueous adjuvant controls.
e Change in hind paw vol. aqueous adjuvant Change in test paw vol.
Change in body weight Change in body weight = Relative change in volume.

Anthraquinone had the most preventive antiarthritic activity recorded of the three Aloe compounds
tested. Anthraquinone inhibited inflammation 67.3%, which was the largest response next to anthranilic
acid. Anthracene had no antiarthritic activity, but a 17.6% inhibition of inflammation was obtained in the
inflammatory paws. This is about one third the effect seen with anthraquinone and anthranilic acid. A
good positive anti-inflammatory response was also obtained with cinnamic acid (32.0%).
Figure 2
Regression of Arthritis. Anthranilic
acid had no antiarthritic activity in the
regressive phase, unlike its ability to
prevent the onset of the disease (Table 2;
Fig. 2). On the other hand, anthraquinone
showed anti-inflammatory activity, but
exhibited no anti-immune response in the
regression phase. Cinnamic acid exhibited
no anti-inflammatory effect, but a 17.3%
regression of the immune response was
recorded. This is somewhat opposite to the
effect measured against prevention of
arthritis. Since the anthraquinones show
activity that helps to explain the overall
response seen with Aloe, future studies
should evaluate other ingredients such as Regression of adjuvant arthritis with anthraquinones.
amino acids, enzymes, vitamins, and
saponins.

Table 2

Regression of Adjuvant Arthritis with Anthraquinones in Rats a,b
Protocol Aqueous Anthraquinone Anthracene Cinnamic Anthranilic
Adjuvant Acid Acid
Control c
Treatment (mg/kg x 13)
Days 0 to 12 150 150 150 150
Number of rats 12 12 12 12 12
Final body weight (g) 333 +/- 12 315 +/- 8 320 +/- 14 329 +/- 16 336 +/- 9
Edema of hind paws (volume units +/- SE)
Day 28 Left 1.67 +/- 0.13 1.71 +/- 0.14 1.80 +/- 0.12 1.62 +/- 0.09 1.67 +/- 0.05
Right 3.07 +/- 0.78 2.61 +/- 0.25 3.38 +/- 0.26 3.13 +/- 0.30 3.00 +/- 0.29
Day 35 Left 1.76 +/- 0.14 1.84 +/- 0.18 1.89 +/- 0.12 1.74 +/- 0.11 1.77 +/- 0.11
Right 3.41 +/- 0.27 3.00 +/- 0.25 3.69 +/- 0.29 3.91 +/- 0.44 3.52 +/- 0.32
Day 38 Left 0.65 +/- 0.09 0.80 +/- 0.10 0.87 +/- 0.36 0.52 +/- 0.06 1.53 +/- 0.12
Right 1.63 +/- 0.15 1.26 +/- 0.13 1.96 +/- 0.16 1.82 +/- 0.17 1.65 +/- 0.19
Percent inhibition d
Day 21 Left -22.9 -34.4 -20.0 -135.0