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research spotlight

The UM Urology Group.

The team has also initiated the collection of biological samples from RCC patients at UMMC and
the growing repository of biological samples serves as an important source of research material
for the evaluation of biomarkers in the serum and tumour tissue. These research discovered
several promising biomarker proteins regulating cell apoptosis and proliferation such as TNF
receptor-associated factor 1 (TRAF1) and nuclear factor kappa-light-chain-enhancer of activated
B cells (NF-κB), as well as the immune response protein, cluster of differentiation 14 (CD14). On
the other hand, the research is paving the way towards investigating the link between obesity
and RCC, specifically by investigating leptin and its receptor, both of which take part in regulating
hunger and energy expenditure. It is believed that the study will provide a clue into the molecular
profiling and pathway analysis of clinically aggressive RCC. Overall, these studies address
both fundamental and clinical issues in the form of translational research work in the hope of
improving patient treatment and management.

For further details regarding urological cancer research, please kindly contact Prof. Dr. Azad Razack
at azadrazack@gmail.com

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