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TOXICOLOGY AND
ALLERGOLOGY OF
DENTAL PLASTIC
MATERIALS Typical examples of lingua plicata - fissured tongue
Typical examples of lingua plicata - fissured tongue
Typical examples of lingua geografica - benign migratory glossitis
Typical examples of lingua geografica - benign migratory glossitis
Adverse effects of composite/adhesive applications in patients:
Adverse effects of composite/adhesive applications in patients:
Lingua plicata (fissured tongue) and Lingua geografica (benign migratory glossitis)
BY PROF. DR. DR. FRANZ-XAVER REICHL, LMU MUNICH. Lingua plicata (fissured tongue) and Lingua geografica (benign migratory glossitis)
ental materials should not from composites and swallowed are The trigger of such reactions has to select the optimal, best tolerated
only look good and last a completely resorbed and broken down now been conclusively identified as filling material for a given patient
Dlong time, they should also to CO2 in the body. It has also been methacrylates HEMA and TEGDMA, before a planned dental restoration.
be well tolerated. Questions about shown that intermediates produced which are commonly used in dental Patients with known allergies
their toxicology/biocompatibility during this metabolism can have strong medicine. In continued personal and intolerance reactions are
have raised a growing interest. toxic effects themselves - leading to research, the release rate of such emphatically advised to consult this
Monomer and co-monomer “poisoning”. During the decomposition compounds was determined for dental toxicology advisory centre
compounds are used in dental of HEMA and TEGDMA in human liver many of the commercially available at LMU before undergoing dental
medicine, e.g. in composites microsomes, the formation of an epoxy composites and adhesives and the restoration. At this centre it can also
and dentin adhesives. These intermediate, 2,3-epoxymethacrylic world’s largest and only database be determined whether the patient
compounds can possibly be acid, has been detected. Epoxy established. In collaboration with the currently has dental material in his
released from these materials and compounds are considered clinics at LMU Munich, allergy tests or her mouth that is responsible for
end up in the human body through carcinogenic and mutagenic. were developed to prove the possible the symptoms. If that is the case,
resorption. For a scientifically supported risk presence of any existing allergies to the patient should have the material
One important aspect in the analysis, it is important to know how substances from dental materials. removed as quickly as possible and
evaluation of toxicology is the much of a substance will be released Selection of the best tolerated replaced by the recommended, best
determination of the resorption, metabo- by a material, how much is actually dental materials before a dental tolerated dental material.
lism and elimination of a substance in absorbed by the organism, and at restoration: Prof. Dr. Dr. Franz-Xaver Reichl
an organism. Only resorbed substances what level do health problems start LMU Munich has recently Outpatient Clinic for Conservative Dentistry
can cause damage. Animal studies manifesting in the organism. In the established the International and Parodontology at LMU and Walther
have shown that the (co)monomers past 10 years, a growing number Advisory Centre for the Tolerance Straub Institute for Pharmacology and
Perioral dermatitis after application of a ceramic inlay
hydroxyethyl methacrylate (HEMA), of patients have shown increased of Dental Materials (www.dentaltox. Toxicology at LMU
triethylene glycol dimethacrylate manifestations of adverse effects com). Today, it is possible after Nussbaumstr. 26 D-80336 Munich Perioral dermatitis after application of a ceramic inlay
with an adhesive
(TEGDMA) and bisphenol glycidyl (e.g. lichenoid reaction, asthma, allergy testing and using the Email: reichl@lmu.de
methacrylate (BisGMA) released eczema) after dental restoration. available, world’s largest database www.dentaltox.com with an adhesive
52 WORD OF MOUTH SUMMER 18/19 WORD OF MOUTH SUMMER 18/19 53
