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Aged Mice Succumb to Multi-organ Failure and Cytokine StormFollowing SystemicImmunostimulatoryTherapy
Young WT (4m)
Aged WT (22m)
Ctrl
Ctrl
Untreated aged mice revealed a preexisting state of mild inflammation even before IT
Serum cytokine marked increases compared with younger mice.
Bouchlaka MN et al. J Exp Med. 2013.
Obesity and Immune Status: “Inflammaging”
• Increased “meta-inflammation” in obesity results in excessive pro-inflammatory responses following systemic immunostimulation (i.e. cytokines, LPS, etc...) which is mediated primarily by macrophages
• What are the effects of obesity on T cell responses when checkpoint blockade to PD1/PDL1 is applied?
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