Page 175 - 2019秋季手冊內頁-ebook測試

RESEARCH INTEREST:
 Molecular Biology, p53 in cancer, Gastrointestinal Cancer, Melanoma
RESEARCH PROJECT:
 A study of matrix gla protein in acral lentiginous melanoma. CMRPG3C1521. 2013/09/01-2014/08/31
 Identification of the biomarkers to predict the response to MDM2 inhibitors in cutaneous melanoma. CMRPG3I045. 2019/2/1-2019/1/31
 To explore biomarkers for non-genotoxic activation of p53 by MDM2 inhibitors in biliary tract cancer. NMRPG3J0011. 2019/03/01- 2020/02/29
 To establish PDX model to explore the novel therapeutic target in KIT/PDGFRA-WT GIST. CMRPG3J0971. 2019/08/01-2022/07/31
PUBLICATIONS (selected 2017~ ):
1. Hsin-Fu Lee, Chiao‐En Wu, Yu-Sheng Lin, Jaw-Shan Hwang, Chu-Hua Wu, Pao-Hsien Chu. Low bone mineral density may be associated with long-term risk of cancer in the middle-aged population: A retrospective observational study from a single center. J Formos Med Assoc. 2018;117(4):339- 345. (SCI; IF 2.844, Medicine, General & Internal, 35/160)
2. Chiao‐En Wu, Arman Esfandiari, Yi-Hsuan Ho, Nan Wang, Ahmed Khairallah Mahdi, Erhan Aptullahoglu, Penny Lovat, *John Lunec. Targeting negative regulation of p53 by MDM2 and WIP1 as atherapeuticstrategyincutaneous melanoma. Br J Cancer.2018; 118(4):495-508. (SCI; IF 5.416; Oncology, 44/229)
3. Wen-Chi Chou, Min-Hsien Wu, Pei-Hung Chang, Hung-Chih Hsu, Gwo-jyh Chang, Wen-Kuan Huang, Chiao‐En Wu, Jason Chia-Hsun Hsieh. A Prognostic Model Based on Circulating Tumour Cells is Useful for Identifying the Poorest Survival Outcome in Patients with Metastatic Colorectal Cancer. Int J Biol Sci. 2018 Jan 12;14(2):137-146. (SCI; IF 4.067; Biochemistry & Molecular Biology, 82/298)
4. Su‐Ching Kuo, Wen‐Chi Chou, Ming‐Mo Hou, Chiao‐En Wu, Wen‐Chi Shen, Fur‐Hsing Wen, Siew‐Tzuh Tang. Changes in and modifiable patient- and family caregiver-related factors associated with cancer patients' high self-perceived burden to others at the end of life: A longitudinal study. Eur J Cancer Care. 2018 Oct 1:e12942 (SCI; IF 2.421; Rehablitation, 5/69)
5. Chiao‐En Wu, Tsin Shue Koay, Arman Esfandiari, Yi-Hsuan Ho, Penny Lovat, *John Lunec. ATM Dependent DUSP6 Modulation of p53 Involved in Synergistic Targeting of MAPK and p53 Pathways with Trametinib and MDM2 Inhibitors in Cutaneous Melanoma. Cancers. 2019;11(1):3. (SCI; IF 6.162; Oncology, 31/229)
6. Chiao‐En Wu, Ming-Huang Chen, and *Chun-Nan Yeh, mTOR Inhibitors in Advanced Biliary Tract
Cancers. Int J Mol Sci, 2019. 20(3). (SCI; IF 4.183; Biochemistry & Molecular Biology, 78/298)
7. Chiao‐En Wu, Tsin Shue Koay, Yi-Hsuan Ho, Penny Lovat, *John Lunec.TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced
apoptotic response. Cancer Cell Int, 2019. 19: 53. (SCI; IF 3.439; Oncology, 92/229)
8. Shang-Yu Wang, Chiao‐En Wu, Chun-Chi Lai,Jen-Shi Chen, Chun-Yi Tsai,Chi-Tung Cheng,Ta-Sen Yeh, *Chun-Nan Yeh.Prospective Evaluation of Neoadjuvant Imatinib Use in Locally Advanced Gastrointestinal Stromal Tumors: Emphasis on the Optimal Duration of Neoadjuvant Imatinib Use,
Safety, and Oncological Outcome. Cancers. 2019;11(3):424. (SCI; IF 6.162; Oncology, 31/229)
9. Chiao‐En Wu, Chin-Yuan Tzen, Shang-Yu Wang, *Chun-Nan Yeh. Clinical Diagnosis of Gastrointestinal Stromal Tumor (GIST): From the Molecular Genetic Point of View. Cancers. 2019;11(3):679. (SCI; IF
6.162; Oncology, 31/229)
10. John Wen-Cheng Chang, Yao-Yu Chang, Yen-Lin Huang, Yun-Feng Lo, Tsung-Ying Ho, Yi-Ting Huang,
Huan-Wu Chen, Chun-Nan Yeh, *Chiao‐En Wu. Merkel cell carcinoma in Taiwan: A series of 24 cases and literature review. Medicine (Baltimore). 2019 Oct;98(42):e17538. (SCI; IF 1.87; Medicine, General & Internal, 69/160)
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