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Nivo+ ISA101 response
All patients Platinum N=22 refractory
n=17
ORR CR PD
8(36%) 6(35%) 2(9%) 2(12%) 12(55%) 10(59%)
A significant correlation of PD-L1 expression with response was demonstrated for tumor score (ORR 43% vs 18%)
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Median duration of response was 10.3 months (95%CI,10.3 months to inestimable),
Median PFS (months)
95% CI (months)
Median OS (months)
95% CI (months)
Nivo+ 2.66 2.5-9.4 Nivo+ 17.5 17.5-NA ISA 101 ISA 101
Erminia Massarelli,et al. JAMA Oncology. 2019 Jan
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