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WHAT ARE THE SIDE EFFECTS OF CBD?
Multiple studies, published as early as 1980, suggest
that CBD has minimal side effects and is overall safe
for consumption. Nonetheless, consumers should be
made aware of any known potential drawbacks
when consuming a health supplement product.
Below, we discuss findings from each recorded study
and review the safety and known side effects of CBD.
1980: STUDY IN PHARMACOLOGY
On January 3, 1980, Pharmacology published their findings
from a study in which eight healthy volunteers and 15
patients with epilepsy consumed CBD daily for one
month to assess its potential side effects. Their
reported conclusions were:
referred to as “cotton mouth." They
“All patients and volunteers tolerated CBD very found that when CBD interacts with the
well and no signs of toxicity or serious side endocannabinoid system, it inhibits the
effects were detected on examination.” secretion of saliva, thus leaving some
users with a dry sensation in their mouth.
1986: INTERNATIONAL JOURNAL OF NEUROSCIENCE 2011: SAFETY AND SIDE EFFECTS
OF CANNABIDIOL
In 1986, oral doses of cannabidiol ranging from 100mg
to 600mg per day were given to five patients with Most recently, in 2011, a review on the
dystonic movement disorders. In addition to recording safety and side effects of cannabidiol
specific benefits, this study also uncovered mild side found that CBD might affect the hepatic
effects of CBD such as hypotension, dry mouth, drug metabolism, alteration of in vitro cell
psychomotor slowing, lightheadedness, and sedation. viability, decreased fertilization capacity
or the reduced activity of p-glycoprotein.
It is also noteworthy that during this study, two patients
who were given CBD in doses over 300mg per day Have you ever been told by a doctor or
seemed to have aggravated Parkinson’s symptoms. pharmacist not to drink or eat grapefruit
However, a 2014 study conducted by the Journal while taking a prescription medication? In
of Psychopharmacology concluded that CBD fact, grapefruit and CBD have a similar
significantly improves the quality of life of those effect on P450, an enzyme found in the
with Parkinson’s disease. liver, which metabolizes different kinds of
medications in the human body. If taken
2006: EXPERIMENTAL BIOLOGY AND MEDICINE in large doses, CBD can inhibit the me-
tabolizing properties of P450, temporarily
In 2006, a group of Argentinian scientists hypothesized neutralizing the effects of other medicinal
that there are cannabinoid receptors in human salivary products in the body’s system. This side
glands. In fact, their hypothesis was correct, which con- effect is also why CBD counteracts some
firmed a previous study which concluded that CBD users effects of THC.
may experience the side effect commonly
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