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Wageningen and gene editing
§ Pioneers on CRISPR-CAS CRISPR-CASR j
§ In Bacteria to avoid Virus infections d X] RQI8F
§ Developed to scissors and glue method to edit genome 6!,( $\K?LEYb,(W
§ USA discovered CD163 edit and more Z)!N CD163YbU<D
§ CRISPR-CAS is one of more techniques available,Talen,Crispr-cas12
CRISPR-CASA"PR<D H.cBTalen Crispr-cas12
§ In Wageningen we have access to commercial gene editing technology
*O`2G/1 : " P' ,(Yb<D
§ BUT: What to edit: Gene Discovery A Yb 3 ,(!N
§ CD163/CD169 CD163/CD169
§ Added Value v.s. Costs for loss of delta-G, product development and market access and
permission risks f Delta-G %6!$4+ R=09C ^"ihSJa
§ Find relevant edits is not easy ; S RYb5 3@
§ Knowledge increasing T_-e
§ Role of genes / impact knock-outs ,(/7&>gR P
§ Pig population different from humans M[ V #
