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Best Therapy for your Patients

ONLINE Haemodiafiltration – The Therapy of Choice Patient Safety and Minimisation of Undesirable Incidences

ONLINE Haemodiafiltration, with its numerous positive effects on uraemia-related
cardiovascular risk factors, is currently acknowledged as the most effective dialysis
treatment modality that comes closest to the elimination profile of the natural kidney.

Haemodiafiltration Reduces Mortality and Morbidity

Deaths/100 patient years minimise operational errors
Deaths (%) • Self-evident programme settings

• Breakthrough technology safety sys-
41 42 tems – e. g. various leakage sensors

The results of two recent studies demonstrate that patients treated with ONLINE (at the extracorporeal blood circuit,
HDF had a significant 35 % reduction of mortality risk compared to patients treated the DIASAFE plus-filters and the
®
(1)
(2)
with standard haemodialysis (Jirka et al. and Canaud et al. ) hydraulics)

High-Flux HD ONLINE HF Patient Surveillance Systems

least 61
at month
showing per 39 30 33 41 35

patients episode 26 17 17

of 1 11 4 4 9 11 4 9 9
% 2

Hypotension Arrhythmia Muscular Pruritus Vomiting
43 Hypertension Dypnea cramps Headache Nausea
Furthermore, convective therapies reduce dialysis-associated side-effects and
intradialytic symptoms compared to standard haemodialysis (Altieri et al. ) Blood Temperature Monitor BTM:
(3)
Effective haemodynamic stabilisation
and recirculation measurement
These clinical benefits of ONLINE HDF therapy are attributed to the more effec-
tive elimination of a broader spectrum of uraemic toxins, combined with minimal
stimulation of inflammation and oxidative stress.
1. Jirka T, Cesare S, Di Benedetto A et al.: The impact of online HDF on patient survival: Results from a large network database.
Nephrol Dial Transplant 2005; 20 (Suppl 5): v18-v19
2. Canaud B, Bragg-Gresham J, Marshall MR et al: Mortality risk for patients receiving hemodiafiltration versus hemodialysis: European
results from the DOPPS. Kidney Int 2006; 69: 2087-2093
3. Altieri P, Sorba GB, Bolasco PG et al.: Online predilution hemofiltration versus ultrapure high-flux haemodialysis, a multicentre pro
spective study in 23 patients. Blood Purif 1997; 15: 169-181

5008 – Achieving Cardioprotective Haemodialysis