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breath hold in expiration, pre- and post-therapy. Multiplanar reformatted images were
generated and reviewed with both soft tissue and lung windows. 140 ml ULTRAVIST®
370. Contrast Volume Discarded: 0 ml. BUN/Creatinine not required.
Computed tomography findings were as follows:
1) Pre-therapy: there was anterior bowing of the posterior membranous trachea
consistent with expiration; there was significant respiratory motion artifact which likely
represented difficulty with breath holding and/or mild respiratory distress; there was mild
hyper expansion; evaluation of pulmonary vasculature was limited by respiratory motion
artifact but grossly normal.
2) Post-therapy: there was anterior bowing of the posterior membranous trachea
consistent with expiration; there was minimal respiratory motion artifact present only at
the lung bases; the lungs were normally expanded; there was normal pulmonary
vasculature.
3) The thyroid appeared normal. Minimal normal residual thymus was demonstrated.
There was no axillary, mediastinal, or hilar lymphadenopathy. The airways were patent.
There was no focal consolidation, pleural effusion or pneumothorax. There were no
pulmonary nodules. The cardiac silhouette was normal without pericardial effusion. The
aorta was normal in size. There was normal three-vessel anatomy. The pulmonary
artery was normal in size.
4) Limited images through the upper abdomen demonstrated normal upper abdominal
contents. Bone windows demonstrated no aggressive appearing osseous lesions. There
was no scoliosis or spinal asymmetry. There were no vertebral body anomalies. The
subcutaneous soft tissues appeared normal.
Radiologist/Physician interpreted that mildly hyperexpanded lungs with significant
respiratory motion artifact was consistent with difficulty breath holding and/or mild
respiratory distress in the pre-therapy scans; and normally expanded lungs with only
minimal respiratory motion artifact was consistent with significant response to therapy in
the post-therapy scans.
Four days after the treatment, D.S. reported that he had not had to use rescue inhaler
since the initial visit. Furthermore, he did baseline running events without the need of
bronchodilation pre- or post-events.
TABLE 5 Summary for patient D. S. Time point Pre-treatment Pre-TX FEV1 2.61 2.83
PEF 359 383 O2 Rest 98 98 O2 Exercise N/A Exercise time N/A CCQ N/A Dose
Unless defined otherwise, all technical and scientific terms used herein have the same
meanings as commonly understood by one of skill in the art to which the disclosed
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