Page 9 - Maxx Cell BMAC Booklet - 2019_RV3_Neat
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The Importance of cfu-f Counts
Authoritative studies in orthopedics (Hernigou et al) demonstrated statistical significance in non-union and osteonecrosis to the
number of cfu-f cells in the graft.
In those same studies, nucleated cells in the graft did not rise to significance
Interestingly, cfu-f is found frequently in marrow and very rarely in peripheral blood.
From Hernigou “Therefore, it seems reasonable to suggest that a graft needs to contain greater than 1000 progenitors / cm ^3”
Cfu-f has been established as the gold standard in determining the quality of a biologic in orthopedic regenerative medicine
Hernigou et al Treatment of Osteonecrosis with autologous bone marrow grafting Clinical Orthopaedics and Realted Research number 405, pp 14-23
Hernigou P, et al Percutaneous Autologous Bone-Marrow Grafting for Nonunions – Influence of the Number and Concentration of Progenitor Cells The Journal of
Bone and Joint” Volume 87-A No 7 July 2005
