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Contents
                 Introduction ................................................................................................................................. 3

                 Test availability at launch can be underestimated, under-budgeted and under-resourced: An
                 example using real-time, real world analysis of PD-L1 ................................................................ 4

                 PD-L1: A chance to get things right? ........................................................................................... 8
                 Diagnostics ignored in targeted therapy pricing, access and value ........................................... 10
                 Complementary testing in PD-L1 – a groundbreaking concept? ................................................ 12

                 The return on investment of better CDx planning based on early PD-L1 observations in NSCLC
                  ................................................................................................................................................. 17

                 The Knight’s move in PD-L1 chess ........................................................................................... 21
                 How big can Merck's Keytruda be in lung cancer? It’s too early to call in the PD-L1 arms race! 23
                 The PD-L1 case: Immune checkpoint inhibitors and the lack of robust biomarkers ................... 24

                 Leave no patient behind: How the FDA approval of Keytruda for specific biomarkers will put
                 laboratory testing in the front line .............................................................................................. 29






















































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