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O  Oedema

A  Appetite increase

T  Teratogenicity

E  enzyme inducer

Ethosuxamide

+2
Mechanism  decrease Ca current (T type)

Uses  Absence seizures

Adverse effects  GIT distress and CNS effects

Gabapentin

Analogue of GABA

+2
Mechanism  Block Ca channels

Uses

 Generalized tonic closure seizures

 Partial seizures

Adverse effects  ataxia and dizziness

Benzodiazepines

-
Mechanism  Bind GABA receptor subunit  opening of Cl channels
(increase frequency of opening of channels)

Uses

 All except absence seizures ( Generalized tonic clonic, Partial and
myoclonic seizures) [Clonazepam]

Barbiturates

Contents Phenobarbitone

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman