Page 29 - FAR 222 Laboratory Manual V2 2019
P. 29
FAR 222 Dosage Form II Laboratory Manual
5. Borate Buffer (pH range 6.8 to 9.1)
Sodium chloride required for
pH Boric acid (g/L) Borax (g/L)
isotonicity (g/L)
6.8 12.03 0.57 2.7
7.2 11.66 1.15 2.7
7.4 11.16 1.91 2.7
7.7 10.54 2.87 2.6
7.8 9.92 3.82 2.6
8.0 9.30 4.78 2.5
8.1 8.68 5.73 2.4
8.2 8.06 6.69 2.3
8.4 6.82 8.60 2.1
8.6 5.58 10.51 1.9
8.7 4.96 11.46 1.8
8.8 3.72 13.37 1.4
9.0 2.48 15.28 1.1
9.1 1.24 17.20 0.7
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