Page 58 - AAOMP Meeting 2019

POSTER ABSTRACTS - TUESDAY, JUNE 11, 2019

#67 THE LINK BETWEEN ORAL LICHEN PLANUS AND SYSTEMIC DISEASES
Ms. Anjali Dave (Columbia University College of Dental Medicine), Dr. Elizabeth Philipone (Columbia
University College of Dental Medicine)
Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease that is seen in 2% of the general
population and presents clinically as white striations and plaques or as erythematous or erosive lesions.
Although the pathologic mechanism of OLP is not yet established, it is accepted that immune dysregulation
plays a critical role. Various researchers have reported associations between OLP and systemic conditions
including: thyroid disease, hepatitis C infection, hypertension, dyslipidemia, diabetes mellitus, and a genetic
predisposition to cancer. The goal of this study was to investigate the association between OLP and the
following systemic conditions: thyroid disease, hepatitis C infection, hypertension, dyslipidemia, diabetes
mellitus, and cancer prevalence.
Methods: This retrospective case-control study was based on patients diagnosed with OLP at Columbia
University from 2000-2013. 156 OLP patients matched the selection criteria. An odds ratio with a 95%
confidence interval was calculated to determine the association between OLP and the systemic diseases
examined.
Results: The OLP subjects were 2.77 times more likely to have thyroid disorders than the controls (95% CI
2.23 to 3.31). An association between the occurrence of OLP and prevalence of any type of cancer was
observed. Specifically there was a strong association between OLP and head and neck squamous cell
carcinoma. The other systemic diseases showed no positive association with OLP.
Conclusions: To the best of our knowledge, this is the only study correlating thyroid disorders and OLP on a
U.S. population. Our findings confirmed that thyroid disorders had a higher association with OLP than that of
the control group. The results from this study suggest there is a correlation between OLP and the occurrence of
oral cancer and all types of cancer in general. We speculate that immune dysregulation plays a role in this
association. Further research with larger sample size is needed.

#68 LOCALIZED JUVENILE SPONGIOTIC GINGIVAL HYPERPLASIA - REPORT OF SEVEN
CASES AND REVIEW OF THE LITERATURE
Mr. Aadel Soleymani (Columbia University College of Dentistry), Ms. Aava Soleymani (Mount Sinai
Medical Center, New York), Dr. Naomi Ramer (Mount Sinai Medical Center, New York)
INTRODUCTION: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is an entity of unknown
etiology that presents clinically as a red papillary lesion of the attached gingiva. This gingival pathology was
first described by Darling et al. in 2007 as “juvenile spongiotic gingivitis”. They noted the prevalence of
LJSGH in children and young adults, as well as the characteristic histopathology of epithelial hyperplasia
with prominent spongiosis, neutrophilic exocytosis, and increased vascularity of the lamina propria.
Subsequently, Chang et al reported 52 additional cases and proposed the term LJSGH. The pathogenesis
remains to be elucidated, but origin from gingival sulcular epithelium has been proposed as CK19
immunohistochemical stain, a marker of sulcular epithelium, demonstrates full-thickness positivity. This
article presents 7 new cases of this entity, discusses our immunohistochemical findings, and reviews the
current available literature.
METHODS: 7 Cases of LJSGH were retrieved from the files of the Mount Sinai Oral Pathology Biopsy
Service. A review of the literature found an additional 158 cases. Clinical and demographic data were collected
and recorded in a database. RESULTS:
All seven of our cases were localized. 165 total cases were reviewed with 28 multifocal cases noted and the
remainder(83%) being solitary. No significant sex predilection was noted in our cases or in the literature.
Similar to the literature we noted a predilection for the anterior maxilla. Four of our cases involved children
under 20-years-old while 3 were adults. In the literature, 90.3% of cases affected children under 20. CK19
stain demonstrated full-thickness, diffuse positivity in our seven cases and all were excised with no recurrence
at follow-up of 1-27 months.
CONCLUSION: We present seven new cases of LJSGH and reviewed 158 cases reported in the literature
to date. Interestingly, multiple cases that were neither localized nor juvenile were noted.