Page 39 - Cardiac Electrophysiology | A Modeling and Imaging Approach

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Figure 2.22. Effects of mutations on KCNQ1 and I current. A. Energy landscapes of wild-type
Ks
KCNQ1 and mutants E160Q, E160A, and E160K. B. Macroscopic KCNQ1 currents corresponding to
these mutations. Blue traces are simulated currents, computed from the protein structure and
energy landscape as outlined in Fig. 2.21. Black traces are experimentally recorded currents
shown for comparison. C. I (KCNQ1/KCNE1) currents for the same mutations (blue-simulated;
Ks
black-recorded); KCNE1 effect was introduced by slowing S4 movement during gating. From Silva
et al. [101], with permission.