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OUR FOUNDATIONS THE PRINCESS MARGARET CANCER FOUNDATION


               Above and Beyond




               Donors remain committed to fueling cancer research in uncertain times


               The past year highlighted one unwavering truth:   be used to evaluate quality of life and treatment
               cancer remains a top priority for our supporters.   responses, and estimate life span in palliative
               Generous donors went above and beyond to          patients. A sincere thank you to Canadian gold
               support life-saving cancer research, helping us   mining company Agnico Eagle, who pledged
               grant $113M to the Princess Margaret Cancer       an outstanding $10M to fund in part the Grand
               Centre—a new record! Here are just some of the    Challenges competitions in the areas of early
               ways in which our supporters are enabling the     detection and high-definition therapeutics.
               biggest and brightest minds in science to tackle
               one of our world’s greatest challenges.           INVESTING IN RESEARCH
                                                                 Through the Invest in Research program, donors
               TAKING ON GRAND CHALLENGES                        get a front-row seat to the future of cancer care
               The Princess Margaret Cancer Foundation, in       and vote on which research project they believe
               partnership with generous donors, provided funds   will have the greatest impact on conquering cancer.
               to support bold, high-impact research through the   Thanks to their exceptional generosity, three
               inaugural Princess Margaret Grand Challenges.     scientists received funding for their transformative
               Four grants of $500,000 were awarded in the areas   research: Dr. Geoffrey Liu for advancing the early
               of early detection, high-definition therapeutics,   detection of lung cancers and relapsing tumours;
               digital intelligence and human touch in cancer    Dr. Catherine O’Brien for identifying ways to
               care. Through these investments, scientists are   target colorectal cancer cells that evade treatment
               exploring the use of liquid biopsies in the early   by entering a dormant state; and Dr. Anna
               detection and targeted treatment of lung cancers.   Spreafico for finding ways to detect and monitor
               They are also testing whether the Hexoskin smart   skin cancer cells that persist after treatment.
               shirt—currently used to monitor astronauts— can


               TRANSFORMING THERAPIES AND CANCER CENTRE SPACE This year, the Longo’s Charitable
               Family Foundation made a landmark gift of $2.5M towards two major areas of impact—UHN’s Tumour
               Immunotherapy Program and the cancer centre’s Space Transformation initiative. Funding emerging research
               in immunotherapy is part of the philanthropic vision of the Longo family (pictured below). This generous
               donation will advance targeted treatments to increase survival rates in the years ahead.























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