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688   Neonatal Losses



                                                   Measure to the
                                                   last rib                        Insert catheter
  VetBooks.ir                                                                        to the mark









                                             3
                                       Mark at  /4
                                       measured
                                        distance
           NEONATAL LOSSES  Preparing for tube feeding. The distance from the tip of the nose to the last rib should
           be measured first. Then, with a permanent marker, 75% of that distance should be measured and marked on
           the catheter. (From Rickard V: Birth and the first 24 hours. In Peterson ME, et al, editors: Small animal pediatrics,
           St. Louis, 2010, Saunders.)



              hematocrit reductions compared with   •  Hypothermia:  gradual  correction  over  30
              adult normal ranges.              minutes to 2 hours at a maximal rate of   NEONATAL LOSSES  Passing the orogastric tube.
           •  Compare serum gamma-glutamyl transferase   1°F (0.5°C) per 30 minutes to avoid delayed   While holding the neonate upright with its neck flexed
            (GGT) and alkaline phosphatase (ALP) levels   organ failure          (not extended), insert the tip of the tube along the roof
            to assess transfer of colostrum.  •  If immune compromise due to insufficient   of the mouth, following the path of least resistance.
            ○   Adequate  colostral  transfer:  neonate’s   colostrum ingestion, frozen colostrum, or   (From Rickard  V: Birth and the first 24 hours. In
              serum  levels  should  be  30  (GGT)  to   fresh-frozen  plasma  (FFP)  administration:   Peterson ME, et al, editors: Small animal pediatrics,
                                                                                 St. Louis, 2010, Saunders.)
              100 (ALP) times higher than adult values   FFP  can  be  given  PO  (<24-hour-old
              during days 1-3 of life.          neonate), IP, SQ, or IV: 3-5 mL/lb (6-10 mL/
           •  FeLV/FIV test                     kg); maximum of 10 mL/dose. FFP should
            ○   Positive FIV test can be due to maternal   not be mixed with any solution, including   should  be  at  a  temperature  of  85°F-95°F
              antibody rather than infection of kitten.  milk replacer, IV fluids, or water. The first   (29.4°-35°C)  with  a  relative  humidity  of
           •  Fecal flotation                   3 doses should be given at birth, 12 hours,   55%-65%.
           •  Thoracic and abdominal radiographs  and 24 hours.
            ○   Lack of fat causes poor serosal detail on   •  Start administering broad-spectrum bacte-  Chronic Treatment
              abdominal images.                 ricidal antibiotics (e.g., ceftiofur [Naxcel]   •  Supportive care
                                                2.5 mg/kg SQ q 12h for 5 days, which is   •  Use commercial milk replacement if mother’s
           Advanced or Confirmatory Testing     considered very safe and has minimal effects   milk is not available. Caloric requirements
           •  Urine culture                     on intestinal flora).              are 155 kcal/kg/d for week 2, 175-198 kcal/
           •  Infectious disease tests, as appropriate  •  Correct dehydration with warmed, balanced   kg/d  for  week  3,  and  220 kcal/kg/d  for
            ○   Serologic titers: Brucella canis, canine her-  crystalloid fluids (lactated Ringer’s solution   week 4.
              pesvirus, Toxoplasma, Neospora, parvovirus   or Normosol-R and 5% dextrose 1 mL/30 g
              antigen test                      body weight IP or intraosseous [IO] initially,   Drug Interactions
            ○   Polymerase chain reaction (PCR) test is   then as needed based on response).  •  Avoid  drugs  contraindicated  for  neonates
              confirmatory for herpesvirus.   •  Correct  hypoxemia  by  administration  of   (e.g.,  glucocorticoids,  immunosuppressive
            ○   Virus isolation                 oxygen at 30%-40%.                 agents, nonsteroidal antiinflammatory drugs
           •  Blood typing (purebred cats)    •  Vitamin K 1 0.01-0.1 mg SQ once because   [NSAIDs], fluoroquinolones, tetracyclines,
           •  Pleural/abdominal fluid analysis  puppies < 2 days old have reduced thrombin   aminoglycosides, trimethoprim-sulfadiazine,
           •  Ultrasound of the skull for patients present-  levels                and chloramphenicol).
            ing with hydrocephalus            •  Correct hypoglycemia if present (p. 552).  •  Drug absorption, metabolism, and excretion
           •  Necropsy of any/all animals that die  •  Correct hypokalemia if present (p. 516).  in dog or cat neonates differ from those
                                              •  After  the  patient  is  stable,  provide  sup-  of adults and vary according to the drug;
            TREATMENT                           portive nursing. In  weaker patients with   detailed drug information should be obtained
                                                an inadequate suckle reflex, tube feeding is   before use in neonates.
           Treatment Overview                   better than bottle feeding because it is a
           Treatment  is generally  supportive, based on   more reliable method to minimize possibility   Possible Complications
           the test results and affected body systems. Not   of aspiration (p. 1117). During the first   •  Transient organ injury (e.g., GI, respiratory)
           all treatments need to be instituted at once   week of life, feeding guidelines for kittens   from the disease process
           because it is very easy to overstress puppies   are 100-175 kcal/lb (220-380 kcal/kg); for   •  Fluid volume overload
           and kittens of such young age. Assess organ   puppies, requirements are 105-120 kcal/lb   •  Aspiration pneumonia
           involvement and institute/revise treatments as   (230-260 kcal/kg) divided equally into 6-8   •  Death of additional members of litter
           clinical signs dictate.              feedings daily.
                                              •  Viral replication can be inhibited by main-  Recommended Monitoring
           Acute General Treatment              taining body temperature above 101°F-102°F   •  Body  weight  q  12h  is  very  important  to
           •  Management of specific disorders if present   (38.3°-38.8°C). Clinicians should monitor   identify early changes and the need for
            (e.g.,  isoerythrolysis  in  kittens  [p.  686],   neonates closely to avoid overheating (not   heightened nutrition/diagnostic testing/
            canine herpesvirus [p. 466])        more  than  103.5°F  [39.7°C]).  Incubator   treatment. Puppies and kittens should gain

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