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764   Patent Ductus Arteriosus


            rupture is frequently the chief source of the   Chronic Treatment     PEARLS & CONSIDERATIONS
            lameness being treated.           •  Same as in acute cases but may require long-  Comments
  VetBooks.ir  Acute General Treatment        •  Disease-modifying agents        •  Severity of lameness may not correlate with
                                                term medical management for the treatment
                                                of osteoarthritis
                                                                                   grade of patellar luxation. Animals with grade
           Medical management:
           •  Nonsteroidal
                        antiinflammatory
            (NSAIDs) in dogs           drugs    ○   Polysulfated glycosaminoglycan 4-5 mg/  2 luxation are often the most painful because
                                                  kg IM once to twice weekly for 4-6 weeks
                                                                                   their patellae are repeatedly grinding across
            ○   Carprofen 2 mg/kg PO q 12h, or  ○   Pentosan  polysulfate  3 mg/kg  SQ  once   the trochlear ridges. Animals with higher-
            ○   Deracoxib 1-2 mg/kg PO q 24h, or  weekly; 10 mg/kg PO or SQ weekly up   grade luxations are not painful but are instead
            ○   Meloxicam 0.1 mg/kg PO q 24h, or  to 4 weeks                       impeded by joint misalignment.
            ○   Grapiprant 2 mg/kg PO q 24h     ○   Oral formulations (glucosamine, chondroi-  •  Patellar luxation is usually a developmental
           Physical rehabilitation for mild patellar luxa-  tin sulfate, avocado soy unsaponifiables):   condition, and the grade of luxation may
           tions (grade 1 ± grade 2):             according to labeled instructions  increase as the animal matures.
           •  Exercises to strengthen quadriceps muscle                          •  In bilateral luxations, the grade of patellar
            function                          Nutrition/Diet                       instability may differ between stifles.
           Surgical management:               Weight control (p. 1077)           •  Soft-tissue stabilization techniques alone are
           •  Soft-tissue reconstruction                                           not sufficient to stabilize moderate or severe
            ○   Imbrication of loose and release of tight   Possible Complications  luxations.
              pericapsular tissues based on direction of   Medical management:   •  Block or wedge trochleoplasty is the preferred
              luxation; release of the rectus femoris or   •  Gastrointestinal,  hepatic,  renal,  or  other   method to deepen the femoral trochlear
              sartorius muscle for MPL          systemic reactions to NSAIDs       groove because it preserves the articular
            ○   Derotational suture from fabella to patella   •  Continued progression of degenerative joint   cartilage.
              or tibial tuberosity              disease                          •  In  older  animals  with  chronic  patellar
           •  Trochleoplasty  to  deepen  the  femoral   •  Failure of medical management to control   instability and acutely worsening lameness,
            trochlear groove                    pain                               concomitant cranial cruciate ligament
            ○   Trochlear chondroplasty in immature dogs  Surgical management:     rupture is likely.
            ○   Abrasion trochleoplasty       •  Patellar reluxation (occurs in 10%-30% of
            ○   Block or wedge recession trochleoplasty  cases, especially in dogs when tibial tuberosity   Prevention
           •  Tibial  tuberosity  transposition  opposite   transposition has not been done)  Screening and control of breeding animals for
            to direction of luxation (very common in   •  Implant failure/tibial tuberosity avulsion  prevention of patellar luxation
            dogs, sometimes omitted in cats because it
            is associated with a higher complication rate)  Recommended Monitoring  Technician Tips
           •  Femoral  or  tibial  corrective  osteotomies:   •  Laboratory monitoring of animals on NSAID   To take straight craniocaudal views of the femur,
            usually performed when angular deformity   therapy                   image only one limb at a time. Hold the dog
            is severe (>15° varus for the distal femur in   •  Weight, exercise levels, and clinical signs as   in a sitting position, or angle the beam so that
            MPL)                                dictated by the patient’s condition  it is perpendicular to the femur. Do not allow
           •  Stifle  arthrodesis  may  be  performed  as   •  Postoperative rehabilitation enhances clinical   the stifle to splay laterally.
            a salvage  procedure for  severe luxations   recovery.
            not amenable to other treatments (more                               SUGGESTED READING
            functional in small dogs than large ones).   PROGNOSIS & OUTCOME     Kowaleski MP, et al: Stifle joint. In Johnston SA,
           •  Concurrent cranial cruciate ligament rupture                         et al, editors: Veterinary surgery small animal, St.
            should be treated along with the MPL;   •  Generally  good  to  excellent  for  return  to   Louis, 2018, Elsevier, pp 1141-1159.
            osteotomy techniques such as tibial plateau   normal limb function if appropriate tech-  AUTHOR & EDITOR: Kathleen Linn, DVM, MS, DACVS
            leveling osteotomy (TPLO) or tibial tuberos-  niques are used
            ity advancement (TTA) can be modified so   •  Degenerative joint disease progresses (radio-
            that the tibial osteotomy also transposes the   graphically, not necessarily symptomatically)
            tibial tuberosity.                  despite treatment.





                                                                                                         Video
            Patent Ductus Arteriosus                                                    Client Education   Available
                                                                                              Sheet

            BASIC INFORMATION                 Synonym                            dog breeds such as Maltese, Pomeranians,
                                              PDA                                Yorkshire  terriers,  Shetland  sheepdogs,  and
           Definition                                                            toy and miniature poodles
           An arterial shunt between the aorta and pulmo-  Epidemiology
           nary artery is normally present in fetuses but   SPECIES, AGE, SEX    RISK FACTORS
           should constrict and close within 24 hours after   •  All species, but much less common in cats  In-breeding
           birth. Patency (incomplete closure) results in a   •  Recognized most frequently in young animals
           channel, the diameter of which determines the   •  Moderate predominance in females  GEOGRAPHY AND SEASONALITY
           amount and direction of blood flow through                            Breed predispositions may vary due to regional
           the shunt and the impact on the patient. It is   GENETICS, BREED PREDISPOSITION  differences in the gene pool.
           the most common congenital heart defect in   Sporadic or hereditable defect occurring most
           dogs, occurring in 1 of 1000.      frequently in small, relatively nonmuscular

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