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Hyperadrenocorticism: Mitotane Induction for Adrenal Tumor 1425.e1
Hyperadrenocorticism: Mitotane Induction for Adrenal Tumor
VetBooks.ir
Mitotane@ 50-75 mg/kg divided BID
AND
Prednisone @ 0.2 mg/kg/d
Decreased appetite, vomiting, diarrhea,
listlessness, or water intake <60 mL/kg/d
OR
Maximum of 14 days
ACTH stimulation test
Post-ACTH at or above upper Response ideal Post-ACTH lower half
half normal resting range normal resting range
Increase mitotane dose by 50 mg/kg/wk Begin maintenance Continue mitotane and prednisone
Continue prednisone as is Mitotane: 75–100 mg/kg/wk 10–14 days
Treat 10–14 days or until see signs Prednisone: 0.2 mg/kg/d OR until see signs that
that loading complete; loading complete (e.g., reduced
repeat ACTH stim at that time water intake); repeat ACTH stim
at that time
Note: Ideal range is <30 nmol/L pre-and post-ACTH; normal resting range is 10–160 nmol/L.
(From Rand J, Behrend E, Gunn-Moore D, Campbell-Ward M, editors: Clinical endocrinology of companion animals. New York: Wiley-Blackwell, 2013.)
AUTHOR & EDITOR: Ellen N. Behrend, VMD, PhD, DACVIM
Clinical Algorithms
www.ExpertConsult.com
