Page 402 - Cote clinical veterinary advisor dogs and cats 4th

Ciliary Dyskinesia, Primary 174.e3

• Cor pulmonale because of the inconvenience and expense ADDITIONAL SUGGESTED
• Reactive systemic amyloidosis of treating recurrent respiratory disease and READINGS
VetBooks.ir Recommended Monitoring antimicrobial therapy. These treatments may Cavrenne R, et al: Primary ciliary dyskinesia and situs Diseases and Disorders
chronic nasal discharge despite appropriate
inversus in a young dog. Vet Rec 163:54, 2008.
be a nuisance for owners of affected dogs.
• Evaluate thoracic radiographs at least every
Edwards DF, et al: Primary ciliary dyskinesia in the
6-9 months in animals with prior episodes
dog. Probl Vet Med 4:291, 1992.
of pneumonia. Prevention Merveille AC, et al. Clinical findings and prevalence
• Exacerbations of clinical signs due to lower Affected dogs should not be bred; males are of the mutation associated with primary ciliary
respiratory disease should prompt tracheal or often infertile. dyskinesia in Old English sheepdogs. J Vet Intern
bronchial lavage for cytologic examination Med 28:771-778. 2014.
and culture. Technician Tips Merveille AC, et al: CCDC39 is required for assembly
• Culture and sensitivity testing of respiratory Label thoracic radiographs, especially the ven- of inner dynein arms and the dynein regulatory
complex and for normal ciliary motility in humans
washes becomes increasingly important the trodorsal or dorsoventral projections, with right and dogs. Nat Genet 43:72, 2011.
more often an affected animal has been or left markers to help confirm the radiographic Watson PJ, et al: Primary ciliary dyskinesia in
treated with antimicrobials. diagnosis of situs inversus. Newfoundland dogs. Vet Rec 144:718, 1999.
PROGNOSIS & OUTCOME Client Education RELATED CLIENT EDUCATION
• Clients should understand that this is an
Depends on severity of ciliary dysfunction. inherited condition that cannot be cured. SHEETS
Illness can range from occasional episodes • Most affected dogs eventually succumb to How to Count Respirations and Monitor
of upper respiratory infection to severe and repeated respiratory infections or permanent Respiratory Effort
frequent bronchopneumonia. Life span is lung damage. Pneumonia
usually negatively impacted by the condition.
SUGGESTED READING AUTHOR: Leah A. Cohn, DVM, PhD, DACVIM
PEARLS & CONSIDERATIONS Cohn LA, et al: Respiratory defenses in health and EDITOR: Megan Grobman, DVM, MS, DACVIM
disease. Vet Clin North Am Small Anim Pract
Comments 37:845-860, 2007.
Even when episodes of pneumonia are rapidly
addressed, affected dogs are often euthanized

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