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Coccidioidomycosis  186.e1





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                                  Equator
                                   EQUATOR




                                 Tropic of Capricorn
                                  Tropic of Capricorn









           COCCIDIOIDOMYCOSIS  Geographic area in which coccidioidomycosis is endemic. Areas of highest prevalence
           are cross-hatched. (From Rippon JW: Medical mycology, ed 3, Philadelphia, 1988, Saunders, p 436. Reprinted
           with permission.)


























                           A                                    B
                           COCCIDIOIDOMYCOSIS  Spherule of  Coccidioides spp containing visible endospores as observed on cytologic
                           examination. A, Note the pyogranulomatous inflammation, consisting of neutrophils and macrophages surrounding the
                           spherule (20× magnification, Wright stain). B, Similar magnification of a free spherule in an inflammatory exudate (1000×
                           magnification, Wright stain). (Photographs by Jeanne Barsanti © 2004 University of Georgia Research Foundation Inc.)








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