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312   Esophagitis


            PEARLS & CONSIDERATIONS           •  Prevent animals from eating bones, rocks,   Client Education
                                                fish hooks, and other foreign objects.  •  It is important to give water after administra-
           Comments
  VetBooks.ir  Esophageal strictures should be referred as soon   inhibitor and a gastric prokinetic before   •  If any evidence of esophageal dysfunction
                                              •  Routine administration of a proton pump
                                                                                   tion of oral medications.
                                                anesthetic  procedures  is  controversial  but
                                                                                   or dysphagia is noted after an anesthetic
           as possible to specialists who have extensive
                                                                                   procedure, notify the veterinarian at once.
           experience with them. Do not attempt to dilate
                                                associated gastroesophageal reflux. If
           a stricture unless one has the equipment and   may lessen the frequency of anesthesia-  •  Long-term  management  of  patients  with
           substantial experience.              perianesthesia gastroesophageal reflux is   partially resolved strictures requires strict,
                                                suspected, the esophagus should immedi-  lifelong dietary management.
           Prevention                           ately be washed out with water and antacid
           •  Animals  should  be  fasted  before  general   therapy begun.      SUGGESTED READING
            anesthesia to reduce risk of reflux.                                 Bissett  SA,  et  al:  Risk  factors  and  outcome  of
           •  Position  anesthetized  patients  to  reduce   Technician Tips       bougienage for treatment of benign esophageal
            risk  of gastroesophageal  reflux and  inflate   •  Watch closely for any evidence of anesthesia-  strictures in dogs and cats: 28 cases (1995-2004).
            endotracheal tube cuff appropriately.  associated reflux.              J Am Vet Med Assoc 235:844-850, 2009.
           •  Patients should receive food or water after   •  Always give cats fluid or food after admin-  AUTHOR: Michael D. Willard, DVM, MS, DACVIM
            administration of oral medications to prevent   istering pills.      EDITOR: Rance K. Sellon, DVM, PhD, DACVIM
            capsules or tablets from lodging in the
            esophagus (especially cats).


            Esophagitis                                                              Bonus Material   Client Education
                                                                                          Online
                                                                                                         Sheet

            BASIC INFORMATION                 Clinical Presentation                or alkaline fluid or with caustic agents (e.g.,
                                                                                   detergents, alkalis, acids) causes mucosal
           Definition                         HISTORY, CHIEF COMPLAINT             damage and inflammation sometimes extend-
           Acute or chronic inflammation of the esopha-  •  Mild esophagitis may be subclinical.  ing to the deeper layers of the esophagus.
           gus, classically secondary to gastric acid (often   •  Clinical signs may include  •  Volume, frequency, and duration of contact
           due to reflux or persistent vomiting), foreign   ○   Increased swallowing motions, ptyalism  of noxious material with the esophagus affect
           bodies, or medications               ○   Inappetence, hyporexia, and/or odynopha-  the severity of esophageal damage.
                                                  gia (discomfort when swallowing) due to   •  Hypersensitivity  might  (?)  predispose  to
           Synonyms                               pain                             eosinophilic esophagitis.
           Gastroesophageal reflux, reflux esophagitis  ○   Regurgitation (mild to severe) or vomiting
                                                ○   Reluctance to move or lie down
           Epidemiology                         ○   Cats may vocalize after eating as an    DIAGNOSIS
           SPECIES, AGE, SEX                      indication of esophageal pain.  Diagnostic Overview
           Dogs and cats of any age and either sex  •  Affected  patients  may  have  a  history  that   Diagnosis  can  be  suspected  based  on  a  sug-
                                                reveals risk factors (see Risk Factors above).  gestive history (dysphagia after anesthesia or
           GENETICS, BREED PREDISPOSITION                                        protracted vomiting) or response to treatment,
           Brachycephalic  dogs  may  be  prone  to  hiatal   PHYSICAL EXAM FINDINGS  but other diseases may respond to therapy for
           hernia, which can cause reflux esophagitis.  May be normal; abnormalities may include  esophagitis. Esophagitis can be easily confirmed
                                              •  Thin body condition             by  direct  endoscopic  visualization.  Biopsy  is
           RISK FACTORS                       •  Dehydration
           •  General anesthesia, even of short duration  •  Ptyalism
            ○   Most commonly reported cause of reflux   •  Pharyngitis, stomatitis, and/or glossitis
              esophagitis in the dog and cat  •  Cranial abdominal/thoracic discomfort
           •  Hiatal  hernia  or  other  causes  of  lower   ○   Hunched-up appearance
            esophageal sphincter (LES) dysfunction  ○   Guarding or pain on palpation
           •  Esophageal foreign body
           •  Oral medications (e.g., tetracyclines, cipro-  Etiology and Pathophysiology
            floxacin, nonsteroidal antiinflammatory drugs   Etiology:
            [NSAIDs]) given without being followed by   •  Premedications (atropine, benzodiazepines,
            food or water administration        phenothiazines, opioids) and anesthetic
           •  Persistent vomiting               induction  agents  may decrease  LES tone,
           •  Gastric hyperacidity (e.g., gastrinoma)  allowing gastroesophageal reflux.
           •  Pythium insidiosum infection    •  Anatomic abnormalities (e.g., hiatal hernia)
           •  Large cranial abdominal masses (e.g., primary   can increase risk of reflux esophagitis.
            hepatic tumors) that displace the stomach   •  Because of their pH or osmolarity, ingested
            dorsally                            medications or chemicals can damage the
                                                esophagus if retained in the esophagus for
           ASSOCIATED DISORDERS                 long periods.                    ESOPHAGITIS  Endoscopic view of a patient with
           Benign  esophageal  strictures,  especially  sec-  Pathophysiology:   esophagitis. Note the longitudinal, darker, patchy areas
           ondary to severe anesthesia-associated reflux     •  Esophageal  mucosal  contact  with  low-pH   indicative of inflammation and mucosal erosion. Fluid
           (p. 310)                             gastric fluid, pepsin, trypsin, bile salts, and/  pooling is apparent at the bottom of the image.

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