Page 774 - Withrow and MacEwen's Small Animal Clinical Oncology, 6th Edition

752 PART IV Specific Malignancies in the Small Animal Patient

and other abdominal organs (e.g., liver, uterus) treated by surgical 16. Thomas R, Smith KC, Gould R, et al.: Molecular cytogenetic
excision alone or in combination with systemic chemotherapy (if analysis of a novel high-grade canine T-lymphoblastic lymphoma
demonstrating co-expression of CD3 and CD79a cell markers,
metastasis is present) can enjoy long-term survival in the majority
VetBooks.ir of cases. 797,864–866,870,875–877,880 In a compilation of nine dogs with 17. Thomas R, Smith KC, Ostrander EA, et al.: Chromosome aberra-
Chromosome Res 9:649–657, 2001.
colorectal plasmacytoma, two dogs had local recurrence at 5 and
8 months after surgery, and the overall MST was 15 months after tions in canine multicentric lymphomas detected with comparative
genomic hybridisation and a panel of single locus probes, Br J Can-
surgery alone. 879 DNA ploidy and Myc oncoprotein expression cer 89:1530–1537, 2003.
in biopsy samples were determined to be prognostic for EMPs in 18. Starkey MP, Murphy S: Using lymph node fine needle aspirates
dogs; however, those that were malignant were all from noncuta- for gene expression profiling of canine lymphoma, Vet Comp Oncol
neous sites (i.e., lymph node, colon, spleen). Therefore location 2010(8):56–71, 2010.
appears to be as predictive. 897 As previously discussed, the major- 19. Lindblad-Toh K, Wade CM, Mikkelsen TS, et al.: Genome
ity of cases of SOP will eventually develop systemic disease; how- sequence, comparative analysis and haplotype structure of the
ever, long disease-free periods usually precede the event. domestic dog, Nature 438:803–819, 2005.
The prognosis in cats is less well-defined because of the pau- 20. Hahn KA, Richardson RC, Hahn EA, et al.: Diagnostic and prog-
city of reported cases. If disease is confined to a local site and/ nostic importance of chromosomal aberrations identified in 61
dogs with lymphosarcoma, Vet Pathol 31:528–540, 1994.
or regional nodes, surgical excision and chemotherapy can result 21. Elvers I, Turner-Maier J, Swofford R, et al.: Exome sequencing of
in long-term control; however, early, widespread metastasis and lymphomas from three dog breeds reveals somatic mutation pat-
progression to MM is also reported in cats. 771,785,857,882,884,885,896 terns reflecting genetic background, Genome Res 25:1634–1645,
2015.
References 22. Mudaliar MA, Haggart RD, Miele G, et al.: Comparative gene
expression profiling identifies common molecular signatures of
NF-kappaB activation in canine and human diffuse large B cell
1. Boerkamp KM, Teske E, Boon LR, et al.: Estimated incidence rate lymphoma (DLBCL), PLoS One 8:e72591, 2013.
and distribution of tumours in 4,653 cases of archival submissions 23. Thomas R, Demeter Z, Kennedy KA, et al.: Integrated immuno-
derived from the Dutch golden retriever population, BMC Vet Res histochemical and DNA copy number profiling analysis provides
10(34), 2014.
2. Dorn CR, Taylor DO, Frye FL, et al.: Survey of animal neoplasms insight into the molecular pathogenesis of canine follicular lym-
phoma, Vet Comp Oncol 15:852–867, 2017.
in Alameda and Contra Costa Counties, California. I. Methodol- 24. Tonomura N, Elvers I, Thomas R, et al.: Genome-wide association
ogy and description of cases, J Natl Cancer Inst 40:295–305, 1968.
3. Dorn CR, Taylor DO, Schneider R: The epidemiology of canine study identifies shared risk loci common to two malignancies in
golden retrievers, PLoS Genet 11:e1004922, 2015.
leukemia and lymphoma, Bibl Haematol 403–415, 1970.
4. Merlo DF, Rossi L, Pellegrino C, et al.: Cancer incidence in pet 25. Ulve R, Rault M, Bahin M, et al.: Discovery of human-similar gene
fusions in canine cancers, Cancer Res 2017(77):5721–5727, 2017.
dogs: findings of the Animal Tumor Registry of Genoa, Italy, J Vet 26. Nasir L, Argyle DJ: Mutational analysis of the tumour suppressor
Intern Med 22:976–984, 2008.
5. Kaiser H: Animal neoplasia: a systemic review. In Kaiser H, editor: gene p53 in lymphosarcoma in two bull mastiffs, Vet Rec 145:23–
24, 1999.
neoplasms-comparative pathology in animals, plants and man, Balti- 27. Pelham JT, Irwin PJ, Kay PH: Genomic hypomethylation in neo-
more, 1981, Wiliams & Wilkins.
6. Moulton JE, Harvey HJ: Tumors of lymphoid and hematopoietic plastic cells from dogs with malignant lymphoproliferative disor-
ders, Res Vet Sci 74:101–104, 2003.
tissue. In Moulton JE, editor: tumors of domestic animals, ed 3, 28. Setoguchi A, Sakai T, Okuda M, et al.: Aberrations of the p53
Berkley, CA, 1990, Univeristy of California Press.
7. Jemal A, Tiwari RC, Murray T, et al.: Cancer statistics, 2004, CA tumor suppressor gene in various tumors in dogs, Am J Vet Res
62:433–439, 2001.
Cancer J Clin 54:8–29, 2004.
8. Ernst T, Kessler M, Lautscham E, et al.: Multicentric lymphoma in 29. Sueiro FA, Alessi AC, Vassallo J: Canine lymphomas: a morpholog-
ical and immunohistochemical study of 55 cases, with observations
411 dogs - an epidemiological study, Tierarztl Prax Ausg K Klein- on p53 immunoexpression, J Comp Pathol 131:207–213, 2004.
tiere Heimtiere 44:245–251, 2016.
9. Villamil JA, Henry CJ, Hahn AW, et al.: Hormonal and sex impact 30. Veldhoen N, Stewart J, Brown R, et al.: Mutations of the p53 gene
in canine lymphoma and evidence for germ line p53 mutations in
on the epidemiology of canine lymphoma, J Cancer Epidemiol the dog, Oncogene 16:249–255, 1998.
2009:591753, 2009.
10. Edwards DS, Henley WE, Harding EF, et al.: Breed incidence of 31. Sokolowska J, Cywinska A, Malicka E: p53 expression in canine
lymphoma, J Vet Med A Physiol Pathol Clin Med 52:172–175,
lymphoma in a UK population of insured dogs, Vet Comp Oncol 2005.
1:200–206, 2003.
11. Priester WA, McKay FW: The occurrence of tumors in domestic 32. Modiano JF, Breen M, Burnett RC, et al.: Distinct B-cell and T-cell
lymphoproliferative disease prevalence among dog breeds indicates
animals, Natl Cancer Inst Monogr1–210, 1980.
heritable risk, Cancer Res 65:5654–5661, 2005.
12. Breen M, Modiano JF: Evolutionarily conserved cytogenetic 33. Carioto LM, Kruth SA, Betts DH, et al.: Telomerase activity in
changes in hematological malignancies of dogs and humans—man clinically normal dogs and dogs with malignant lymphoma, Am J
and his best friend share more than companionship, Chromosome Vet Res 62:1442–1446, 2001.
Res 16:145–154, 2008.
13. Devitt JJ, Maranon DG, Ehrhart EJ, et al.: Correlations between 34. Nasir L, Devlin P, McKevitt T, et al.: Telomere lengths and telomer-
ase activity in dog tissues: a potential model system to study human
numerical chromosomal aberrations in the tumor and peripheral telomere and telomerase biology, Neoplasia 3:351–359, 2001.
blood in canine lymphoma, Cytogenet Genome Res 124:12–18, 2009.
14. Thomas R, Fiegler H, Ostrander EA, et al.: A canine cancer-gene 35. Yazawa M, Okuda M, Kanaya N, et al.: Molecular cloning of the
canine telomerase reverse transcriptase gene and its expression in
microarray for CGH analysis of tumors, Cytogenet Genome Res neoplastic and non-neoplastic cells, Am J Vet Res 64:1395–1400,
102:254–260, 2003.
2003.
15. Thomas R, Seiser EL, Motsinger-Reif A, et al.: Refining tumor- 36. Thamm DH, Grunerud KK, Rose BJ, et al.: DNA repair deficiency
associated aneuploidy through ‘genomic recoding’ of recurrent as a susceptibility marker for spontaneous lymphoma in golden
DNA copy number aberrations in 150 canine non-Hodgkin lym- retriever dogs: a case-control study, PLoS One 8(e69192), 2013.
phomas, Leuk Lymphoma 52:1321–1335, 2011.