Page 1334 - Veterinary Immunology, 10th Edition

generalized lymphadenopathy, hepatomegaly, and splenomegaly.
VetBooks.ir There is a loss of lymphocytes from the T-dependent areas of the

secondary lymphoid organs. B cell areas show an initial hyperplasia
of the secondary follicles followed by the loss of these follicles and

of plasma cells. These changes are very similar to those seen in
AIDS in humans. In many cases, normally innocuous agents such as
Pneumocystis, cytomegalovirus, C. parvum, and Candida albicans
cause infection. Some affected monkeys develop tumors such as

fibrosarcomas. About half of the infected animals develop
neutralizing antibodies and survive the disease. The others die from
septicemia or diarrhea with wasting.

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