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19 – THE PYREXIC CAT  385


           Prognosis for the pneumonic form is guarded to fair.  Age range of cats with documented disease was 2–10
                                                          years of age, with no breed or sex predilection
           Prognosis for septicemic form is guarded.
                                                          reported.
           Persistent fever > 40˚C (104˚F) despite treatment is
                                                          Infection has a variable effect on appetite, from mild
           associated with a poor prognosis.
                                                          inappetence to anorexia and mild to moderate weight
                                                          loss.
           Transmission
                                                          Chronic intermittent fever in the moderate range is
           Y. pestis has a serious zoonotic potential, and great
                                                          common.
           care should be taken in suspect cats to prevent trans-
           mission to humans and other cats.              Lymphadenopathy was reported in three of 23 cats.
            ● Infected cats are no longer a zoonotic risk after
                                                          Hyperesthesia,  joint pain or irritable disposition is
              3 days of antibiotic therapy.
                                                          common.
           Transmission occurs via rodent flea bites or inges-
                                                          Complete blood counts may show a non-regenerative
           tion of infected animals.
                                                          anemia with a leukopenia or a leukocytosis; thrombo-
           Infection can also occur via inhalation of aerosolized  cytopenia is present in about 25% of the cats.
           organism, either from aspirates of infected tissue or
                                                          Biochemistry abnormalities are uncommon, except for
           nasal discharge/sneezing of cats with pneumonic
                                                          hyperglobulinemia in about 33% of documented cases.
           form.
                                                          Diagnosis
           Prevention
                                                          A complete blood count and biochemistry panel consis-
           Confine cats indoors in endemic areas.         tent with chronic Ehrlichia spp. infection is suggestive.
           Discourage hunting behavior especially during the peak  Diagnosis is by demonstrating E. canis and/or Anaplasma
           flea season (April to October).                phagocytophilum serum antibody titers or a positive
                                                          IFA test.
           Provide effective flea control to prevent flea bites.
                                                          Demonstration of morulae in mononuclear cells, neu-
                                                          trophils or eosinophils (rare) is diagnostic.
           EHRLICHIA SPP. AND ANAPLASMA                   PCR assays can be positive.
           PHAGOCYTOPHILUM*

                                                          NEOPLASIA
            Classical signs
            ● Anorexia and weight loss.                    Classical signs
            ● Fever.
                                                           ● Anorexia, lethargy, weight loss.
            ● Lymphadenopathy.
                                                           ● ± Fever.
            ● Lameness.
                                                           ● Signs depend on tumor type and organ
            ● Non-specific hyperesthesia.
                                                             system involved.
           See main reference on page 547 for details (The Anemic
           Cat).                                          Clinical signs

                                                          Anorexia, lethargy and weight loss.
           Clinical signs                                 Poorly groomed coat.
           This disease is uncommonly reported in cats and is  Some cats have a fever associated with neoplasia,
           difficult to diagnose because of its vague and variable  which is generally a secondary neoplastic syndrome.
           clinical signs.                                Tumors which destroy the bone marrow and result in
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